抑那通治疗前列腺癌的新进展

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1、抑那通治疗前列腺癌的新进展AUA(2010)内分泌治疗新进展Radiotherapycombinedwithandrogendeprivationvs.androgendeprivationaloneinclinicallylocallyadvancedprostatecanerinamulticenterrandomisedphaseIIIstudyNicolasMottet,France.AUA(2010)内分泌治疗新进展INTRODUCTIONANDOBJECTIVESInlocallyadvanceddisease,thecombinationofrad

2、iotherapy(RT)andandrogendeprivation(ADT)issuperiortoRTalone.ButADTwithananaloguehasneverbeencomparedtocombinedmodality.WereportaphaseIIIrandomisedtrialinlocallyadvancedPCa,comparingacombinedmodalityandADTonly.AUA(2010)内分泌治疗新进展METHODSInthisFrenchmulticenter,open,randomisedtrial,patien

3、tslessthan80years,withhistologicallyconfirmedPCa,T3-4,orpT3(biopsy)N0M0wereincluded.Theywerecentrallyrandomisedin2parallelgroupstoeitherADTalone(leuprorelin11.25mgSR,1scinjectionevery3monthsfor3yearsorthesameADTcombinedwithRTstartingwithin3monthsover7weeks.AUA(2010)内分泌治疗新进展RESULTSHTH

4、T+RTPN131133MeanAge70.570.70.63MeanPSAbaseline51.7741.500.79MedianPFS(days)126425440.0005PFS(5year)(%)15.464.70.0005Biologicalprogression(%)71.519.5<0.0001Clinicalprogression(%)37.711.3<0.0001AUA(2010)内分泌治疗新进展Prevalenceofmetabolicsyndromeinprostatecancerpatientsunderandrogendeprivati

5、ontherapy:interimresultsofacase-controlstudy.JorgeRopero,Barcelone,Spain.AUA(2010)内分泌治疗新进展INTRODUCTIONANDOBJECTIVESCardiovascularmortalityisthemostimportantcauseofdeathinpatientswithprostatecancer(PC).Thedevelopmentofmetabolicsyndrome(MS)inpatientsundergoingandrogendeprivationtherapy

6、(ADT)hasbeenrelatedwiththisincreaseinmortalityrate.TheaimofthisstudyhasbeentoconfirmthehypothesisthatADTincreasestheprevalenceofMS.AUA(2010)内分泌治疗新进展METHODSAgroupof157patientswereenrolledinthisinterimanalysisofaprospectivecasecontrolstudy.53PCpatientsunderADTduringameantimeof52months(

7、6to252)and104agematchedcontrolsevaluatedatthetimeofprostatebiopsy(52withcancerand52without)wereincluded.AUA(2010)内分泌治疗新进展METHODSMSwasanalyzedaccordingtheATPIIIpanelcriteria:Fastingplasmaglucoselevel>110mg/dLserumtriglyceridelevel>150mg/dLserumhigh-densitylipoproteinlevel<40mg/dLwaist

8、circumferenc