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1、ARTICLEINPRESSBiomaterials26(2005)6296–6304www.elsevier.com/locate/biomaterialsNano-compositeofpoly(L-lactide)andsurfacegraftedhydroxyapatite:Mechanicalpropertiesandbiocompatibilitya,ba,ba,ba,ba,bZhongkuiHong,PeibiaoZhang,ChaoliangHe,XueyuQiu,AixueLiu,a,ba,b,a,bLiChe
2、n,XuesiChen,XiabinJingaStateKeyLaboratoryofPolymerPhysicsandChemistry,ChangchunInstituteofAppliedChemistry,ChineseAcademyofSciences,Changchun130022,ChinabGraduateSchoolofChineseAcademyofSciences,Beijing100039,ChinaReceived2February2005;accepted7April2005Availableonlin
3、e23May2005AbstractInordertoimprovethebondingbetweenhydroxyapatite(HAP)particlesandpoly(L-lactide)(PLLA),andhencetoincreasemechanicalpropertiesofthePLLA/HAPcompositeaspotentialbonesubstitutematerial,theHAPnano-particlesweresurface-graftedwithPLLAandfurtherblendedwithPL
4、LA.Thestructureandpropertiesofthecompositesweresubsequentlyinvestigatedbythemechanicalpropertytesting,thedifferentialscanningcalorimetermeasurements(DSC),thescanningelectronmicroscopy(SEM),thepolarizedopticalmicroscopy(POM),andthecellculture.ThePLLAmoleculesgraftedont
5、heHAPsurfaces,asinter-tyingmolecules,playedanimportantroleinimprovingtheadhesivestrengthbetweentheparticlesandthepolymermatrix.Atalowcontent(4wt%)ofsurfacegrafted-HAP(g-HAP),thePLLA/g-HAPnano-compositesexhibitedhigherbendingstrengthandimpactenergythanthepristinePLLA,
6、andatahigherg-HAPcontent(e.g.,20wt%),themoduluswasremarkablyincreased.ItimpliedthatPLLAcouldbestrengthenedaswellastoughenedbyg-HAPnano-particles.Theresultsofbiocompatibilitytestshowedthattheg-HAPexistinginthePLLAcompositefacilitatedbothadhesionandproliferationofchondr
7、ocytesonthePLLA/g-HAPcompositefilm.r2005ElsevierLtd.Allrightsreserved.Keywords:Polylactide;Hydroxyapatite;Composite;Mechanicalproperties;Biocompotibility;Cellculture1.Introductionwerelowerthanthoseofnaturalcorticalbones.Thus,forpreparingadesiredmaterialthatpresentshigh
8、mechanicalInordertoavoidthesecondoperationimposedonboneperformancetomatchnaturalbones,inorganicfillersweredefectpatientfortak
