Plasticity of the visual system after early brain damage资料

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1、DEVELOPMENTALMEDICINE&CHILDNEUROLOGYREVIEWPlasticityofthevisualsystemafterearlybraindamage1,23412ANDREAGUZZETTA

2、GIULIAD'ACUNTO

3、STEPHENROSE

4、FRANCESCATINELLI

5、ROSLYNBOYD

6、1,3GIOVANNICIONI1DepartmentofDevelopmentalNeuroscience,StellaMarisScientificInstitute,Pisa,Italy

7、.2QueenslandCerebralPalsyandRehabilitationResearchCentre,SchoolofMedicine,UniversityofQueensland,Brisbane,Australia.3DivisionofChildNeurologyandPsychiatry,UniversityofPisa,Italy.4CentreforMagneticResonance,UniversityofQueenslandCentreforClinicalResearch,Brisbane,

8、Australia.CorrespondencetoDrAndreaGuzzettaatDepartmentofDevelopmentalNeuroscience,StellaMarisScientificInstitute,ViadeiGiacinti,2I-56018Calambrone,Pisa,Italy.E-mail:a.guzzetta@inpe.unipi.itPUBLICATIONDATATheaimofthisreviewistodiscusstheexistingevidencesupportingd

9、ifferentprocessesofvisualAcceptedforpublication29thMarch2010.brainplasticityafterearlydamage,asopposedtodamagethatoccursduringadulthood.ThereisPublishedonline15thJune2010.initialevidencethatsomeoftheneuroplasticmechanismsadoptedbythebrainafterearlydamagetothevisu

10、alsystemareunavailableatalaterstage.Theseare,forexample,theabilitytodifferentiatefunctionaltissuewithinalargerdysplasticcortexduringitsformation,ortodevelopnewthalamo-corticalconnectionsabletobypassthelesionandreachtheircorticaldestinationintheoccipitalcortex.The

11、youngbrainalsousesthesamemechanismsavailableatlaterstagesofdevelopmentbutinamoreefficientway.Forexample,inpeoplewithvisualfielddefectsofcentralorigin,theanatomicalexpansionoftheextrastriatalvisualnetworkisgreaterafteranearlylesionthanafteralaterone,whichresultsinmo

12、reefficientmechanismsofvisualexplorationoftheblindfield.Asimilarmechanismislikelytosupportsomeofthedifferencesfoundinpeoplewithblind-sight,thephenomenonofunconsciousvisualperceptionintheblindfield.Inparticular,comparedwithpeoplewithlatelesions,thosewithearlybraindam

13、ageappeartohavestrongersubjectiveawarenessofstimulihittingtheblindvisualfield,reportedasaconsciousfeelingthatsomethingispresentinthevisualfield.Expandingourknowl