资源描述：
《Mol Cell. 2005, V19, 857-864》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、MolecularCell,Vol.19,857864,September16,2005,Copyright©2005byElsevierInc.DOI10.1016/j.molcel.2005.08.027RegulationofLSD1HistoneShortArticleDemethylaseActivitybyItsAssociatedFactorsYu-JiangShi,1,4CaitlinMatson,1,3FeiLan,1,3residues(suchasH3-K4)isassociatedwithactivetran-ShigekiIwase,2Ta
2、dashiBaba,2andYangShi1,*scription(Kouzarides,2002;ZhangandReinberg,2001).1DepartmentofPathologyThus,methylationrepresentsacriticalposttranslationalHarvardMedicalSchoolmodificationofhistonesthatimpactschromatinstruc-77AvenueLouisPasteurtureandgenetranscription(Bannisteretal.,2002;Boston
3、,Massachusetts02115LachnerandJenuwein,2002;ZhangandReinberg,2001).2GraduateSchoolofLifeandEnvironmentalSciencesUnlikeotherhistonemodificationssuchasacetyla-andInstituteofAppliedBiochemistrytionandphosphorylation,methylationhaslongbeenUniversityofTsukubathoughttobeapermanentmodification
4、.ChallengingTsukubaScienceCitythisdogma,therecentdiscoveryofthelysine-specificIbaraki305-8572histonedemethylase,LSD1,stronglysuggeststhathis-Japantonemethylationcanberegulateddynamicallyviabothhistonemethylasesanddemethylases(Shietal.,2004).LSD1(aliasKIAA0601,p110b,npao,andBHC110)isanS
5、ummaryamineoxidase,whichmediateshistonedemethylationviaFAD-dependentoxidativereaction(Shietal.,2004),LSD1isarecentlyidentifiedhumanlysine(K)-spe-andhasbeenidentifiedinanumberofcorepressorcifichistonedemethylase.LSD1isassociatedwithcomplexesincludingCoREST,CtBP,andasubsetofHDAC1/2;CoRES
6、T,aSANTdomain-containingcore-HDACcomplexes(Ballasetal.,2001;Hakimietal.,pressor;andBHC80,aPHDdomain-containingpro-2002,2003;Humphreyetal.,2001;Shietal.,2003;Youtein,amongothers.WeshowthatCoRESTendowsetal.,2001).Consistentwiththesefindings,LSD1hasLSD1withtheabilitytodemethylatenucleosom
7、albeenshowntofunctionasatranscriptionalcorepres-substratesandthatitprotectsLSD1fromproteaso-sorbydemethylatingK4ofhistoneH3(Shietal.,2004),maldegradationinvivo.Wefindhyperacetylatedwheremethylationislinkedtoactivetranscription(Li-nucleosomeslesssusceptibletoCoREST/LSD1-medi-angetal.,
