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1、Anal.Chem.2006,78,3887MicroTotalAnalysisSystems.LatestAdvancementsandTrendsPetraS.Dittrich,KaoruTachikawa,andAndreasManz*InstituteforAnalyticalSciences,Bunsen-Kirchhoff-Strasse11,D-44139Dortmund,GermanyReviewContentsoverviewofthenovelachievements,andtoassistnewcomerstoTechnologies3887thefield.Inth
2、etraditionoftheformerreviews(8-10),thispaperMicrofabrication3887focusesonnoveldevelopmentsoffluidicsystemsforappliedBondingTechniques3888analyticalpurposes.Forthisreason,publicationsaboutsensors,SurfaceModification3888arrays(so-calledªbiochipsº),chemicalsynthesesonmicrochips,Design3889theory,andsi
3、mulationsaswellasreviewandtrendarticleshaveInterfacesandInterconnections3889beenomitted.Furthermore,wereducedthetechnologysection,FlowControl3889asthemajorityofworkiscarriedoutbyemployingsimpleplanarAnalyticalStandardOperations3890microchipsfabricatedinglassorpolymerssuchassiliconeSamplePreparatio
4、n3890elastomer.However,weobservedastaggeringriseinpublicationsInjection3891relatedtocellularapplications;therefore,thesectionwasnaturallyFluidandParticleHandling3891ReactorsandMixers3892expanded.Separation3892Detection3893TECHNOLOGIESApplications3895Microfabrication.Materials.Microfluidicsystems,f
5、abricatedCellHandlingandAnalysis3895byutilizingbiomaterials,havegatheredenormousattentionintheBiomimeticandBiopoweredSystems3897recentyears.Cabodietal.fabricatedtheentiresystemwithinClinicalDiagnosis3898calciumalginate,aversatilehydrogel(11).Gelatin,cross-linkedImmunoassays3898withthenaturallyoccu
6、rringenzymetransflutaminase,wasmoldedDNA3899byPaguiriganandBeebetoproducechannelssuitableforProteins3900adherentcellcultureandanalysis(12).A3DdevicemadeentirelyOtherBioassays3900fromprototypical,biodegradablethermoplasticwasdevelopedbyEnvironmentalConcernsandGasAnalysis3901LiteratureCited3901Kinge
7、tal.(13).Burdicketal.introducedthefabricationofgradienthydrogelsusingamicrofluidicsandphotopolymerizationTheareaofmicrototalanalysissystems(íTAS),alsocalledprocess(14).ªlabonachipº,miniaturizedormicrofluidicanaly
