2016-[review]microfluidic tools toward industrial biotechnology

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1、MicrofluidicToolsTowardIndustrialBiotechnologyAlineF.OliveiraDepartmentofBioprocessesandMaterialsEngineering,SchoolofChemicalEngineering,UniversityofCampinas,500AlbertEinsteinavenue,Campinas,P.O.Box6066AmandaC.S.N.PessoaDepartmentofBioprocessesandMaterialsEngineering,SchoolofChemicalE

2、ngineering,UniversityofCampinas,500AlbertEinsteinavenue,Campinas,P.O.Box6066ReinaldoG.BastosDepartmentofAgroindustrialTechnologyandRuralSocioeconomy,CenterofAgriculturalSciences,FederalUniversityofS~aoCarlos,Km174AnhangueraHighway,Araras,P.O.Box153LucimaraG.delaTorreDepartmentofBiopr

3、ocessesandMaterialsEngineering,SchoolofChemicalEngineering,UniversityofCampinas,500AlbertEinsteinavenue,Campinas,P.O.Box6066DOI10.1002/btpr.2350PublishedonlineSeptember21,2016inWileyOnlineLibrary(wileyonlinelibrary.com)Microfluidicsisatechnologythatoperateswithsmallamountsoffluidsandma

4、kespossi-bletheinvestigationofcells,enzymes,andbiomoleculesandencapsulationofbiocatalystsinagreatervarietyofconditionsthanpermittedusingconventionalmethods.Thisreviewdiscussestechnologicalpossibilitiesthatcanbeappliedinthefieldofindustrialbiotechnolo-gy,presentingtheprincipaldefinition

5、sandfundamentalaspectsofmicrofluidicparameterstobetterunderstandadvancedapproaches.Specifically,concentrationgradientgenerators,droplet-basedmicrofluidics,andmicrobioreactorsareexploredasusefultoolsthatcancon-tributetoindustrialbiotechnology.Thesetoolspresentpotentialapplications,inclus

6、iveascommercialplatformstooptimizinginbioprocessesdevelopmentasscreeningcells,encapsu-latingbiocatalysts,anddeterminingcriticalkineticparameters.VC2016AmericanInstituteofChemicalEngineersBiotechnol.Prog.,32:13721389,2016Keywords:microfluidics,concentrationgradientgenerator,droplet-bas

7、ed,microbioreactor,industrialbiotechnologyIntroductionsystemsthatallowsimulatingdifferentbiologicalandchemi-calenvironmentsthatcanidealizenewanalyticalways.AsaMicrofluidicsisaversatiletechnologicalfieldthatenablesresult,theresearchinsciencesasbiomedical,pharmaceutical,studiesofdynamicc

8、onditions,an