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1、Analysisofmyostatinanditsrelatedfactorsinvariousporcinetissues^J.Jiao,*tT.Yuan,*Y.Zhou,*W.Xie,*Y.Zhao,*J.Zhao,tH.Ouyang,*^andD.Pang*^*JilinProvinceAnimalEmbryoEngineeringKeyLaboratory,GollegeofAnimalScienceandVeterinaryMedicine,JilinUniversity,Ghangchun,Jilin,130062,Ghina;andfGo
2、llegeofAnimalScience,TarimUniversity,Alar,Xinjiang,843300,GhinaABSTRACT:Myostatinisexpressedinskeletalturedfibroblasts.Therelativeabundanceofmyostatinmuscletissuewhereitfunctionstosuppressmyoblastwascloselyrelatedtofollistatinanddecorininporcineproliferationandmyofiberhypertroph
3、y.Recently,myo-tissues.Immunohistochemicalanalysisfurtherdemon-statinwasdetectedinthetendon,mammarygland,andstratedthepresenceofmyostatin,follistatin,anddeco-adiposetissueofmice.Wesoughttodeterminewhetherrinintheskeletalmuscle,adiposetissue,heartmuscle,myostatinisexpressedinthel
4、iver,spleen,lung,andliver,spleen,lung,andkidneyofpigs.Theseresultskidneyofpigs.R,eal-timePGRandWesternblotsdem-suggestthatmyostatincouldbeassociatedwithcer-onstratedthatmyostatin,follistatin,decorin,andac-tainfunctionsoftheinternalorgans,suchasenergytivinreceptorIIB{ActRIIB)mRNA
5、andproteinsweremetabolismorfibrosis.Weconcludethatmyostatinisexpressedinskeletalmuscle,heartmuscle,andadiposeafactorbroadlyexpressedintheinternalorgansandtissue,andalsoinliver,spleen,lung,kidney,andcul-nuiscletissuesofpigs.Keywords:activinreceptorIIB,decorin,expression,follistat
6、in.myostatin,pig'S)2011AmericanSocietyofAnimalScience.Allrightsreserved.J.Anim.Sei.2011.89:30993106doi:10.2527/jas.2010-3827INTRODUCTIONcells.Furthermore,blockingmyostatinfunctionmaybeusefulforslowingorpreventingthedevelopmentofMyostatin,alsoknownasgrowthanddifferentia-type2diab
7、etes(McPherronandLee,2002)andobesitytionfactor-8(GDF-8),isamemberofthetransforming(Ghoietal.,2007).growthfactor-ß(TGF-ß)superfamilyandwasidenti-Manytypesofanimaltissuesandcellsarereportedfiedin1997(McPherronetal,1997).Themajorroletoexpressmyostatin,anditsexpressioninfluencesthei
8、rofmyostatinistosuppressskeletalmusclegrowthand
