PFOS Lecture 1 Membrane Transport

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1、Revision(1)PanelofFoundationStudies`FunctionsofdifferentcellorganellesCellBiology(2013-14)DrLEEKitYing,RebeccaSchoolofBiomedicalSciencesRoom612,Choh-MingLiBasicMedicalSciencesBuilding(rebec.lee@cuhk.edu.hk/39431380)12Revision(2)DifferentTypesofTransportMech

2、anisms`Paracellulartransport:throughtightjunctionsbetweenepithelialcells`3typesofcytoskeleton:`Transcellulartransport:passthroughthecellmembrane`Transcytosis:involvestheformationofvesicles,e.g.endocytosis&exocytosis34CellBiologyPFOS1-12`Cellmembraneandmembr

3、anetransportMembraneTransport`Cytoskeletonandcellmovement`Cellorganelles`Endocyticandsecretorypathways`Celljunctionandcelladhesion`Cellcycleandcelldeathhttp://changingmindsaboutdownsyndrome.blogspot.hk/2011/02/choline.htmlLearningOutcomesOverviewofTransport

4、MechanismsO2`Tounderstandtheimportanceofselectivepermeabilityincell`Plasmamembraneisasemi-GASES/SMALLCO2HYDROPHOBICmembranepermeablemembrane:highlyMOLECULESN2benzeneimpermeabletoions&polarmoleculesSMALLHO`TounderstandvariousmechanismsthatthecellsusetoUNCHAR

5、GED2ureatransportsubstancesacrossthecellmembranePOLARglycerol`Diffusionofgasesoccurrapidly&MOLECULESdependentirelyonconcentration`Todifferentiateandgiveexamplesofsimplediffusion,facilitatedgradientLARGEUNCHARGEDglucosediffusion,primaryactivetransportandseco

6、ndaryactivePOLARsucrose`WaterdiffusesreadilythroughMOLECULEStransportbiologicalmembranesviagapsin++H,Nathehydrophobicenvironment-+HCO3,KIONS2+-Ca,Cl2+Mglipidbilayer78MovementofMoleculesAcrossMembranes(1)MovementofMoleculesAcrossMembranes(2)`Passivetransport

7、`ActivetransportSimplediffusionPrimaryactivetransportTransportofmoleculesfromhightolowconcentrationthroughtheplasmaConsumesATPdirectlytodrivethetransportmembrane(non-selective)PumpsFacilitateddiffusionSecondaryactivetransportTransportofmoleculesfromhightolo

8、wconcentrationFacilitateddiffusionCoupledtransportduetothemovementofothermoleculesChannels/transportersdowntheirrespectiveelectro-Ifatransportedsubstancecarriesanetcharge,itschemicalgradientsmovementis