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1、Downloadedfromjnnp.bmj.comonSeptember21,2011-Publishedbygroup.bmj.com15818ounialofNeurology,Neurosurgery,andPsychiatry1996;60:158-167Comparisonofpositronemissiontomography,cognition,andbrainvolumeinAlzheimer'sdiseasewithandwithoutsevereabnormalitiesofwhitema
2、tterCDeCarli,CLGrady,CMClark,DAKatz,DRBrady,DGMMurphy,JVHaxby,JASalerno,JAGillette,AGonzalez-Aviles,SIRapoportAbstractDAT+group.MultipleregressionanalysisObjectives-Toexaminecerebralmetabo-showedsignificantbetweengroupdiffer-lism,cognitiveperformance,andbrai
3、nencesintherelationbetweentheADratiovolumesinhealthycontrolsandtwoandneuropsychologicalscoresonthreegroupsofpatientswithprobabletasks.TheslopesoftherelationsbetweenAlzheimer'sdisease,onegroupwiththeADratioandmemoryscores(memorysevereabnormalitiesofwhitematte
4、randfreedomfromdistractabilitydeviation(DAT+)andtheothergroupwithnone,orquotientoftheWechsleradultintelligenceminimalabnormalities(DAT-).scale(WMDQ))alsoweresignificantlydif-Methods-Neuropsychologicaltests,CT,ferentforthetwogroups.MRI,quantitativeMRI,andPETs
5、tudiesConclusions-AlthoughmultiplecauseswerecarriedouttoallowcomparisonforabnormalitiesofwhitematterexistinbetweentheDAT+andDAT-groupspatientswithAlzheimer'sdisease,theseandthehealthycontrols.datasuggestthatthepresenceofsevereResults-Comparedwiththehealthyco
6、n-abnormalitiesofwhitematterindicateatrols,bothdementedgroupshadsignifi-secondpathologicalprocessintheDAT+candyreducedglobalandregionalpatients.TheDAT-patientsshowedthecerebralmetabolism,significantbrainparietal-temporalmetabolicdeficitsandLaboratoryofatroph
7、y,andsignificantlylowerscoresoncorrelationsbetweenassociationneocorti-Neurosciences,neuropsychologicaltesting.calmetabolismandneuropsychologicalNationalInstituteonAgingTheDAT-patientgroupshowedapat-taskperformancetypicalofpatientswithCDeCarliternofparietal-t
8、emporalcerebralmeta-Alzheimer'sdisease.Bycontrast,theCLGradybolicreductionsandneuropsychologicalDAT+grouphadapatternofcerebralCMClarkperformancemetabolismsignificantlydifferentfromDAKatzdeficits
