hotodynamictherapy光动力疗法

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1、PhotodynamictherapyCloseupofsurgeons'handsinanoperatingroomwithabeamoflighttravelingalongfiberopticsforphotodynamictherapy.Apatientisgivenaphotosensitivedrugthatisabsorbedbycancercells.Duringthesurgery,thelightbeamispositionedatthetumorsite,whichthenactivatesthedrugthatkillsthecancercellsPhotodynam

2、ictherapyorPDTisatreatmentthatusesspecialdrugs,calledphotosensitizingagents,alongwithlighttokillcancercells.Thedrugsonlyworkaftertheyhavebeenactivatedor“turnedon”bycertainkindsoflight.What’sthephotodynamictherapy?PhotodynamicchemicalreactionprincipleadvantagesWhatarethebasicconditionsofPDT?●Photose

3、nsitizertumorhascertainselectivityandaffinityandforalongertimetoremaininthetumorsite.●Photosensitizerintumortissueproducesingletoxygenwithlight.●Usingappropriatewavelengthsoflighttoexcitethephotosensitizer.PDTadvantages•Lowtoxicity.•Smalltrauma•Repeatability•SelectivityApplication●Helppeoplewithcan

4、certolivelongerandimprovetheirqualityoflife.It’sbecomingmorewidelyrecognizedasavaluabletreatmentoptionforlocalizedcancers.●Usedtotreatpre-cancersoftheskin.ThreephotosensitizingagentsarecurrentlyapprovedbytheUnitedStatesFoodandDrugAdministration(FDA)totreatcertaincancersorpre-cancers.●Porfimersodium

5、(Photofrin®)●Aminolevulinicacid(ALAorLevulan®)●MethylesterofALA(Metvixia®cream)Sideeffects◊Lightallergicreactions.◊Afewdaysaftertreatment,patientsmaysuffertemporarylocalizededemaresponse.ProspectsDevelopinganewphotosensitizewithashorterperiodtoentertumorcellsandcanbequicklyclearedfromthenormalcells

6、isparticularlyimportant,sothatcannotonlyimprovetheefficacy,butalsoreducephototoxicity.Inaddition,developlongwavelengthphotosensitizerinordertoincreasethedepthofillumination.Researchthecauseofphotosensitizerselectivityandaffinityfortumorcellsandthemechanismofantitumorphotosensitizer.Thesearethecomin

7、gurgentproblem.Thanks!