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1、ThePlantCell,Vol.24:482–506,February2012,www.plantcell.orgã2012AmericanSocietyofPlantBiologists.Allrightsreserved.JUNGBRUNNEN1,aReactiveOxygenSpeciesResponsiveNACTranscriptionFactor,RegulatesLongevityinArabidopsisWOAAnhuiWu,a,b,1AnnapurnaDeviAllu,a,b,1PrashanthG
2、arapati,a,bHamadSiddiqui,aHakanDortay,aMaria-Ine´sZanor,bMariaAmparoAsensi-Fabado,cSergiMunne´-Bosch,cCarlaAntonio,bTakayukiTohge,bAlisdairR.Fernie,bKerstinKaufmann,dGang-PingXue,eBerndMueller-Roeber,a,b,2andSalmaBalazadeha,baUniversityofPotsdam,InstituteofBioch
3、emistryandBiology,14476Potsdam-Golm,GermanybMax-PlanckInstituteofMolecularPlantPhysiology,14476Potsdam-Golm,GermanycDepartamentdeBiologiaVegetal,UniversitatdeBarcelona,FacultatdeBiologia,08028Barcelona,SpaindLaboratoryofMolecularBiology,WageningenUniversity,6708
4、PBWageningen,TheNetherlandseCSIROPlantIndustry,St.LuciaQLD4067,AustraliaThetransitionfromjuvenilitythroughmaturationtosenescenceisacomplexprocessthatinvolvestheregulationoflongevity.Here,weidentifyJUNGBRUNNEN1(JUB1),ahydrogenperoxide(H2O2)-inducedNACtranscriptio
5、nfactor,asacentrallongevityregulatorinArabidopsisthaliana.JUB1overexpressionstronglydelayssenescence,dampensintracellularH2O2levels,andenhancestolerancetovariousabioticstresses,whereasinjub1-1knockdownplants,precocioussenescenceandloweredabioticstresstolerancear
6、eobserved.AJUB1bindingsitecontainingaRRYGCCGTcoresequenceispresentinthepromoterofDREB2A,whichplaysanimportantroleinabioticstressresponses.JUB1transactivatesDREB2AexpressioninmesophyllcellprotoplastsandtransgenicplantsandbindsdirectlytotheDREB2Apromoter.Transcrip
7、tomeprofilingofJUB1overexpressorsrevealedelevatedexpressionofseveralreactiveoxygenspeciesresponsivegenes,includingheatshockproteinandglutathioneS-transferasegenes,whoseexpressionisfurtherinducedbyH2O2treatment.MetaboliteprofilingidentifiedelevatedProandtrehaloselev
8、elsinJUB1overexpressors,inaccordancewiththeirenhancedabioticstresstolerance.WesuggestthatJUB1constitutesacentralregulatorofafinelytunedcontrolsystemthatmodulatescellul
