人类疱疹病毒(I)精美生物医学

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1、人类疱疹病毒HumanherpesvirusesContainsseveralofthemostimportanthumanpathogensAspectrumofdiseasesLifelongpersistentinfectionPeriodicreactivationMainpropertiesVirion:spherical,150-200nmcore+capsid+envelopedsDNA,encodesatleast100proteins35proteinsstructureofvirus

2、Replication:InthenucleusBudfromnuclearmembraneEarlyreplicationandlatereplicationCPE:apartfromEBV,otherscancauseCPEincellcultureFormofinfectionReplicationinfection:primary,reactivatedLatentinfectionCongenitalinfection(先天性感染)Celltransformation病毒infectedcel

3、lsdiseasesHSV1粘膜上皮细胞／感觉神经节细胞多种疾病及潜伏感染HSV2粘膜上皮细胞／感觉神经节细胞生殖器疱疹及潜伏感染VZV皮肤细胞／脊髓后根神经节，颅神经的感觉神经节水痘／带状疱疹EBVB细胞，上皮细胞／B细胞传染性单核细胞增多症Burkitt瘤，鼻咽癌CMV上皮细胞，白细胞，精子细胞／分泌腺体多种疾病HHV6CD4+T细胞婴儿丘疹（唾液传播）免疫低下：持续急性感染HHV7CD4+T细胞幼儿皮疹（唾液传播）与其他疾病关系不清HHV8不清Kaposi肉瘤有关Herpessimplexviru

4、s(HSV)PropertiesTwoserotypes:HSV1andHSV2HSVgenome:encodesatleast70proteinssomeassociatedwithviralreplicationsomeenvelopeproteinsassociatedwithimmunereactionviralpenetrationHerpessimplexvirus（HSV）PathogenicitySourceofinfectionpatientsandcarriersRoutesoftr

5、ansmissionHSV1：contactHSV2：sexually/maternalgenitalinfectionPathology:cytolyticinfectionPrimaryinfectionmostareinapparent,butresultinantibodyproductionandlatentinfectionHSV1Gingivitis(齿龈炎):mostfrequentlyKeratoconjunctivitis(角膜结膜炎)SkininfectionEncephaliti

6、sLatentinfection:inthetrigeminalganglia(三叉神经节)HSV2Genitalherpes:commonseenSkinherps:asHSV1Neonatalherpes:duringbirth,isaseverediseaseskin,eye,monthlesionencephalitismultipleorgandisseminated(多器官感染)Latentinfection：sacralganglia(骶神经节)Latentandrecurrenceinf

7、ectionHSV1,HSV2neuronvirusreactivate,replicationaxon(神经纤维)peripheralsites,skinormucousmembraneHSV1：口唇部疱疹HSV2：genitalherpesVaricella-zostervirus（VZV）水痘带状疱疹病毒similarasHSVVZVnakedVZVenvelopedPathogenicitySourceofinfection：patientsRoutesofinfection:respirato

8、rytractDisease：水痘(Varicella/chickenpox)：儿童：斑丘疹，水疱，偶见并发症孕妇：症状较重，可致胎儿畸形，流产，死胎免疫低下：重症水痘Latentinfectiondorsalrootganglia(脊髓后根神经节)Zoster(带状疱疹)SeeninadultsSeverepainandvesicle,ofteninchestCytomegalovirus(CMV)巨细胞病毒Thelargestgenet