analysis of a Trichinella pseudospiralis muscle

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1、AcceptedManuscriptTitle:Cloning,analysisofaTrichinellapseudospiralismusclelarvasecretedserineproteasegeneAuthors:KrystynaCwiklinski,DianaMeskill,MarkW.Robinson,E.Pozio,JudithA.Appleton,BernadetteConnollyPII:S0304-4017(08)00574-8DOI:doi:10.1016/j.vetpar.20

2、08.10.036Reference:VETPAR4579Toappearin:VeterinaryParasitologyPleasecitethisarticleas:Cwiklinski,K.,Meskill,D.,Robinson,M.W.,Pozio,E.,Appleton,J.A.,Connolly,B.,Cloning,analysisofaTrichinellapseudospiralismusclelarvasecretedserineproteasegene,VeterinaryPar

3、asitology(2008),doi:10.1016/j.vetpar.2008.10.036ThisisaPDFfileofanuneditedmanuscriptthathasbeenacceptedforpublication.Asaservicetoourcustomersweareprovidingthisearlyversionofthemanuscript.Themanuscriptwillundergocopyediting,typesetting,andreviewoftheresult

4、ingproofbeforeitispublishedinitsfinalform.Pleasenotethatduringtheproductionprocesserrorsmaybediscoveredwhichcouldaffectthecontent,andalllegaldisclaimersthatapplytothejournalpertain.1CloningandanalysisofaTrichinellapseudospiralismusclelarvasecretedserine2pr

5、oteasegene12133KrystynaCwiklinski,DianaMeskill,MarkW.Robinson,E.Pozio,JudithA.21*4AppletonandBernadetteConnolly15InstituteofMedicalSciences,UniversityofAberdeen,Aberdeen,AB252ZD,Scotland,UK;26JamesA.BakerInstituteforAnimalHealth,CollegeofVeterinaryMedicin

6、e,Cornell37University,Ithaca,NY14853,USA;DepartmentofInfectious,Parasiticand8ImmunomediatedDiseases,IstitutoSuperiorediSanità,vialeReginaElena299,00161Rome,9Italy.10*Correspondingauthor.Tel.:+441224555825;Fax:+441224555844;E-mailaddress:11b.connolly@abdn.

7、ac.uk12Note:NucleotidesequencedatareportedinthispaperareavailableintheGenbank,EMBL13andDDBJdatabasesundertheaccessionno.EU245046.14Abstract15NematodeparasitesofthegenusTrichinellaareintracellularanddistinctlifecyclestages16invadeintestinalepithelialandsk

8、eletalmusclecells.Withinthegenus,Trichinellaspiralis17andTrichinellapseudospiralisexhibitspecies-specificdifferenceswithrespecttohost-18parasitecomplexformationandhostimmunemodulation.Parasiteexcretory-secretory(ES)