资源描述：
《02 Mien-Chie Hung. Novel Target Therapy for Breast cancer》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、NovelTargetTherapyforBreastcancer13thChineseBreastCancerConferenceand9thShanghaiInternationalBreastCancerSymposiumOct24‐252014Presenter:Mien‐ChieHung,Ph.D.VicePresidentforBasicResearchProfessorandChair,MolecularandCellularOncologyDevelopmentofTargete
2、dgeneTherapyforPancreaticandBreastCancerWhydoCetuxumabandAvastinnotworkwellforbreastcancertreatment?DevelopmentDevelopmentofofpancreaticpancreaticspecificspecificexpressionexpressionvector,vector,cc‐‐VISAVISAXie,et.al.CancerCell,2007VISA(CTP):Vp16‐ga
3、l4‐wpreIntegratedSystemicAmpifiercholecystokininAreceptor(CCKAR),mediatorofpancreaticenzymesecreationC-VISAisrobustandpancreaticcancer-specificinanorthotopicxenograftsmodelofAsPC-1innudemiceafteri.v.injectioninDNA:liposomecomplexesSelectionoftherapeu
4、ticgene,BikBik:Bcl-2InteractingKiller•Pro-apoptoticBH3-onlyProtein•BindingtoBcl-2,Bcl-XLandMCL1toinduceapoptosis•PhosphorylationoftheBIKregulatesapoptoticactivity16169134160BH3TMT33S35BikDD(T33DS35D):•Mimicphosphorylationtofurtherenhancepro-apoptotic
5、activityC‐VISA‐BikDDinhibitstumorgrowthandprolongsmousesurvivalinanorthotopicmodel)8Xie,et.al.CancerCell,2007A,x10216Ctrl12CMV-BikDDCTP-BikDD8400714212835424956Signal(Photons/s/cm120B10080Ctrl60CMV-BikDD40CTP-BikDD20Survival(%)00714212835424956FDAapp
6、rovedaphase1trial,DaysPost1stTreatmentMilindJavleandMien‐ChieHung.VISA‐Claudin4‐Lucwasselectivelyexpressedinthemammarytumors,whiletheCMVpromoterwasmainlyexpressedinlungLiang,et.al.CancerCell,2011CancerStemCellsAreResistanttoTraditionalTherapyChemothe
7、rapyRadiationPersistentCancerStemCellsTumorCellPopulationModifiedfromIshencko,et.al.Surgery,2009146:430LownumbersofselectedmammospherecellscaninducetumorinNOD/SCIDmiceevenaftersecondarytransplantationVISA‐claudin4‐BIKDDsensitizedEGFR+/HER2+breastcanc
8、ercellstolapatinibinvitroandinvivoNIHRACapprovedIntheprocesstofileINDforaPhase1clinicaltrialEGFRModulatesmiRNAMaturationinResponsetoHypoxiathroughPhosphorylationofAgo2HypoxiaShenetal,Nature,2013EGFR/Ago2Ago2-Y393-PAgo2/DicerMaturationofasubsetofTS-li
