05 Michael Untch. Clinical advance in (neo)adjuvant HER2 breast cancer

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1、EndocrineTherapy(inductionof13:15-amenorrhea)inERpositvepre-GuangyuLiu13:30Topic2menopausepatients13:30-OptimizationstrategyofQiangLiu13:45individualizedchemotherapy13:45-TreatmentforpremenopauseWalterJonat14:10III：Clinicaladvance：HormonerecepotorpositiveBC14:10-LuminalTreatmentforpo

2、stmenopauseZefeiJiang14:35HormonerecepotorpositiveBC14:35-Clinicaladvancein(neo)adjuvantBinheXuMichaelUntch15:00III：Clinicaladvance：HER2+BreastcancerGuosheng15:00-HER2positiveClinicaladvanceinmetastaticRenPaulGoss15:25HER2+BreastcancerJiongWu15:25-III：TreatmentinEBC：TNBCXichunHu15:50

3、TNBC15:50-Q&A16:00ProfessorMichaelUntchM.D.,PhDDepartmentofObstetricsandGynecologyHeadofDepartmentDirectorBreastCancerCenterBerlinASCORecommendationsforHER2testingpositiveresultsIHCuniformal,intensemembranestaining>30%oftumorcellsFISH>6HER2genecopiespernucleusFISH-ratioHer2genesignal

4、stochromosome17signalsofmorethan2.2WolfA.JClinOncol2007HER2POSITIVITYRATEANDPATIENTAGEN=11.700AdjuvantHerceptin®hasanextensiveevidencebasewith>13,000patientstreatedin4majortrialsHERA(ex-USA)BCIRG006(global)ObservationIHC/FISHFISH1year(n=5090)(n=3222)1year2years1yearNCCTGN9831(USA)NSA

5、BPB-31(USA)IHC/FISHIHC/FISH1year(n=3505)(n=2030)1year1yearDoxorubicin+Docetaxel+StandardCTxcyclophosphamiDocetaxelcarboplatinHerceptin®PaclitaxeldePiccart-Gebhartetal2005;Romondetal2005;Slamonetal2006N9831/B-31Disease-FreeSurvivalACP+H81.4%76.8%73.7%11.5%ACP69.5%64.9%62.2%%Event-Fr

6、eeNEventsAC→P2018680AC→P+H2028473HRadj=0.60(95%CI:0.53-0.68)P<0.0001YearsfromRandomizationNo.atrisk2028195918481747167516111514129391061935020181887168915291423132912321027705449255B-31/N9831OverallSurvival93.2%ACP+H89.8%87.0%84.0%ACP90.3%8.8%84.3%79.4%75.2%∆=2.9%∆=5.5%∆=7.6%∆=8.8%

7、%SurvivalNEventsAC→P2018418AC→P+H2028286HRadj=0.63(95%CI0.54-0.73)P<0.0001YearsfromRandomizationNo.atrisk20281995195918971843178517091506108573543920181962188318061730164015341336944604353NSABPB-31CumulativeIncidenceofCardiacEvents5ACPHarm:37events(4.0%)43HR=3.30;P‐value‐=0.000382ACP

8、arm:10events