熊猫基因组_The sequence and de novo assembly of the giant panda genome_nature08696_2009

熊猫基因组_The sequence and de novo assembly of the giant panda genome_nature08696_2009

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时间:2019-07-11

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1、doi:10.1038/nature08696ARTICLESThesequenceanddenovoassemblyofthegiantpandagenome1,211,314,53,611,7RuiqiangLi*,WeiFan*,GengTian*,HongmeiZhu*,LinHe*,JingCai*,QuanfeiHuang,QingleCai,11866191011BoLi,YinqiBai,ZhiheZhang,YapingZhang,WenWang,JunLi,FuwenWei,HengLi,MinJian,JianwenLi,111

2、21131114ZhaoleiZhang,RasmusNielsen,DaweiLi,WanjunGu,ZhentaoYang,ZhaolingXuan,OliverA.Ryder,1511161711FrederickChi-ChingLeung,YanZhou,JianjunCao,XiaoSun,YongguiFu,XiaodongFang,XiaosenGuo,18811113,61BoWang,RongHou,FujunShen,BoMu,PeixiangNi,RunmaoLin,WubinQian,GuodongWang,ChangYu,

3、66111,791,71,3WenhuiNie,JinhuanWang,ZhigangWu,HuiqingLiang,JiumengMin,QiWu,ShifengCheng,JueRuan,11111111MingweiWang,ZhongbinShi,MingWen,BinghangLiu,XiaoliRen,HuisongZheng,DongDong,11111813131KathleenCook,GaoShan,HaoZhang,CarolinKosiol,XueyingXie,ZuhongLu,HanchengZheng,1,3141511

4、11YingruiLi,CynthiaC.Steiner,TommyTsan-YukLam,SiyuanLin,QinghuiZhang,GuoqingLi,JingTian,116161111717TimingGong,HongdeLiu,DejinZhang,LinFang,ChenYe,JuanbinZhang,WenboHu,AnlongXu,11,3,6191,31,31,311,3YuanyuanRen,GuojieZhang,MichaelW.Bruford,QibinLi,LijiaMa,YiranGuo,NaAn,YujieHu,1

5、,3551111,71YangZheng,YongyongShi,ZhiqiangLi,QingLiu,YanlingChen,JingZhao,NingQu,ShancenZhao,11111202122FengTian,XiaolingWang,HaiyinWang,LizhiXu,XiaoLiu,TomasVinar,YajunWang,Tak-WahLam,2223242424111Siu-MingYiu,ShipingLiu,HeminZhang,DeshengLi,YanHuang,XiaWang,GuohuaYang,ZhiJiang,

6、111111,21,25JunyiWang,NanQin,LiLi,JingxiangLi,LarsBolund,KarstenKristiansen,GaneKa-ShuWong,2611111,2MaynardOlson,XiuqingZhang,SonggangLi,HuanmingYang,JianWang&JunWangUsingnext-generationsequencingtechnologyalone,wehavesuccessfullygeneratedandassembledadraftsequenceofthegiantpan

7、dagenome.Theassembledcontigs(2.25gigabases(Gb))coverapproximately94%ofthewholegenome,andtheremaininggaps(0.05Gb)seemtocontaincarnivore-specificrepeatsandtandemrepeats.Comparisonswiththedogandhumanshowedthatthepandagenomehasalowerdivergencerate.Theassessmentofpandagenespotential

8、lyunderlyingsomeofitsuniquetraitsindicatedthatitsbambo

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