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1、LasersinSurgeryandMedicine39:428440(2007)ImmunohistochemicalCharacterizationofPeriodontalWoundHealingFollowingNonsurgicalTreatmentWithFluorescenceControlledEr:YAGLaserRadiationinDogs12134FrankSchwarz,DDS,*SørenJepsen,MD,DMD,MonikaHerten,AkiraAoki,PhD,DDS,AntonSculean,DMD,1{andJ
2、u¨rgenBecker,DDS1DepartmentofOralSurgery,HeinrichHeineUniversity,D-40225Du¨sseldorf,Germany2Chairman,DepartmentofPeriodontology,BonnUniversity,Bonn,Germany3DepartmentofPeriodontologyandHardTissueEngineering,TokyoMedicalandDentalUniversity,Tokyo,Japan4ChairmanDepartmentofPeriodo
3、ntology,RadboudUniversityMedicalCenter,Nijmegen,TheNetherlandsBackgroundandObjective:Theaimofthepresentningusinghandinstruments.Numerousstudieshavestudywastoimmunohistochemicallycharacterizeperiod-reportedbeneficialresultsfromthistreatmentmodalityontalwoundhealingfollowingnonsur
4、gicaltreatmentwithwithrespecttobothclinicalandmicrobialparametersfluorescencecontrolledEr:YAGlaserradiationindogs.[27].However,itwasalsoobservedthatsuchinstrumen-StudyDesign/MaterialsandMethods:Fivebeagledogstationmaybeassociatedwithextensivecementumremovalsufferingfromnaturally
5、occurringchronicperiodontitisleadingtoincreasedsurfaceroughnessinbothsupra-andwererandomlyallocatedinasplit-mouthdesigntononsur-subgingivallylocatedareas,whichmightenhanceplaquegicalperiodontaltreatmentusingeither(a)anEr:YAGretention[810].Additionally,inrecentyears,power2lasera
6、t10.2,12.8,15.4,18,and20.4J/cm(ERL1-5),or(b)driveninstruments,suchassonicandultrasonicscalersanultrasonicdevice(VUS)servingascontrol.Theanimalshavebeenproposedinordertoenablebetteraccesstoweresacrificedafter3months.Histomorphometrical(e.g.anatomicallydifficultareassuchasfurcation
7、sitesandinflammatorycellinfiltrate,surfacechanges,cementumtoincreasetheefficiencyofsubgingivalinstrumentationformation),andimmunohistochemicalparameters(col-[1115].AlthoughrecentsystematicreviewshavereportedlagentypeI,CD68,matrixmetalloproteinase(MMP)-8)onthecomparativeclinicalout
8、comeofpowerdrivenversuswereassessed.manualinstrumentat
