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1、中华临床医师杂志(电子版)2011年7月第5卷第14期ChinJClinicians(ElectronicEdition),July15,2011,Vol.5,No.14#4043##论著#儿童食物过敏相关性迁延性、慢性腹泻53例的临床特点王娟孙梅【摘要】目的分析食物过敏相关性儿童迁延性、慢性腹泻病的病因、临床特点、治疗以及疗效。方法对2006年9月至2010年3月在中国医科大学附属盛京医院小儿消化内科病房住院,病因未明的诊断为迁延性、慢性腹泻病60例患儿的临床资料进行回顾性分析,其中过敏组53例,非过敏组7例。分析过敏原的分布、相关化验结果的变化情况以及食
2、物过敏相关性迁延性、慢性腹泻的临床特点。结果88133%的患儿存在1~10种不等的食物过敏。IgG抗体检测结果阳性率:牛奶>蛋清蛋黄>西红柿>鳕鱼=大豆>蟹=大米>牛肉=虾=小麦>鸡肉=玉米>蘑菇=猪肉。过敏组IgM高于非过敏组(P=0101),2组中性粒细胞、嗜酸细胞、便常规、肠道菌群、总蛋白、白蛋白、免疫球蛋白差异无统计学意义(P>0105)。经回避过敏原、黏膜保护剂、微生态制剂治疗后患者的腹泻症状多有不同程度的缓解,治疗总有效率差异有统计学意义(P=0101)。结论未知病因的迁延性、慢性腹泻患儿多数存在食物过敏,该类患儿临床表现及常规化验检查与非过敏患
3、儿表现类似。回避过敏原的诊断性治疗后腹泻好转。过敏原检测对儿童未知病因的迁延性、慢性腹泻的诊治具有一定意义。【关键词】食物过敏;慢性腹泻;儿童;口服耐受Clinicalcharacteristicsof53chronicdiarrheainchildrenassociatewithfoodallergyWANGJuan,SUNMei.DepartmentofPediatrics,ShengjingHospitalAffiliatedtoChinaMedicalUniversity,Shenyang110004,ChinaCorrespondingauthor
4、:SUNMei,Email:sunm@sj2hospital.org【Abstract】ObjectiveToanalyzethecause,clinicalcharacteristicsandtreatmenteffectofchildrenwithchronicdiarrheaassociatewithfoodallergy.MethodsTherelatedclinicalinformationsofchildrenwithchronicdiarrheawhoweretreatedindepartmentofpediatricsofshengjingh
5、ospitalfromSeptember2006toMarch2010wererecordedandanalysedindetail.Toanalyzethedistributionofallergen,thevariationofrelatedclinicalinformations.Results88133%chronicdiarrheachildrenhadfoodallergyespeciallyfor1to10foods.ThepositiverateofIgGtest:milk>egg>tomato>cod=soy>crab=rice>beef=
6、shrimp=wheat>chicken=maize>mushroom=pork.IgMofallergygroupwashigherthannon2allergygroup(P=0101).Therewerenosignificantdifferencesbetweenthetwogroupsinneutrophils,acidophilus,stool,intestinalbacteria,totalprotein,albuminandimmunoglobulin(P>0105).Curativeefficacyofavoidallergen,mucos
7、aprotector,microecologicalbacteriaofallergygroupwasfavorableanddifferentfromnon2allergygroup(P=0101).ConclusionsMostofchronicdiarrheainchildrenwhosepathogenesisisstillunknownexistfoodallergy.Thepatientspclinicalcharacterandnormallaboratorytestsaresimilar.Diarrheaarerelievedafterdia
8、gnostictreatmentofavoidall
