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1、IntroductiontoInSituFormingHydrogelsforBiomedicalApplicationsBogyuChoi,XianJunLoh,AloysiusTan,ChunKeatLoh,EnyiYe,MinKyungJooandByeongmoonJeongAbstractInsitugellingpolymeraqueoussolutionsundergosol-to-geltransitionthroughchemicaland/orphysicalcrosslinking.Thecriteriononsolandgel
2、isanimportantissue,therefore,rheologyofhydrogelhavebeendiscussedindetail.Theinsitugellingsystemhasbeeninvestigatedforminimallyinvasivedrugdeliv-ery,injectabletissueengineering,genedelivery,andwoundhealing.Inthischap-ter,insitugellingsystemsandtheirvariousbiomedicalapplicationsw
3、erebrieflysummarized.KeywordsInjectable·Rheology·Physicalcrosslinking·Thermogel·TissueengineeringB.ChoiDivisionofAdvancedProsthodontics,UniversityofCalifornia,LosAngeles,CA90095,USAX.J.Loh(*)·A.Tan·C.K.Loh·E.YeInstituteofMaterialsResearchandEngineering(IMRE),A*STAR,3ResearchLin
4、k,Singapore117602,Singaporee-mail:lohxj@imre.a-star.edu.sgX.J.LohDepartmentofMaterialsScienceandEngineering,NationalUniversityofSingapore,9EngineeringDrive1,Singapore117576,SingaporeX.J.LohSingaporeEyeResearchInstitute,11ThirdHospitalAvenue,Singapore168751,SingaporeM.K.JooCente
5、rforTheragnosis,BiomedicalResearchInstitute,KoreaInstituteofScienceandTechnology,Seoul,SouthKoreaB.Jeong(*)DepartmentofChemistryandNanoScience,EwhaWomansUniversity,52Ewhayeodae-Gil,Seodaemun-Gu,Seoul120-750,SouthKoreae-mail:bjeong@ewha.ac.kr©SpringerScience+BusinessMediaSingapo
6、re20155X.J.Loh(ed.),In-SituGellingPolymers,SeriesinBioEngineering,DOI10.1007/978-981-287-152-7_26B.Choietal.1IntroductionHydrogelsarehydrophilicmacromolecularnetworksswolleninwaterorbiologi-calfluids[1].WichterleandLim[2]reportedthepioneeringworkusinghydro-philic2-hydroxyethylm
7、ethacrylate(HEMA)hydrogelsin1960.Recently,insitugellingsystemsbasedonvariousnaturalandsyntheticpolymershavebeenwidelyinvestigatedforbiomedicalapplicationsduetoeffectiveencapsulationofcellsandbioactivemolecules,minimallyinvasiveinjection,andeasyformationinanydesiredshapeofdefect
8、s,inadditiontoseveraladvantagesoftypicalhydrogelsinclu
