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1、Theimportanceofthisstudyisthatitsuggeststhatotherhormonesonpubertalgrowth.In:GrumbachM,GraveG,MayerthefinalheightofpatientswithTSwhoaretreatedF,eds.ControloftheOnsetofPuberty.Airlie,VA:Wiley&Sons;1972:342±359withGHisincreasedbyusingverylowdosesof7.Att
2、ieKM,ChernausekS,FraneJ,RosenfeldRG.Growthhormoneusesystemicestradiol,ratherthanroutineestrogenther-inTurnersyndrome:apreliminaryreportontheeffectofearlyvsapy,toinducepuberty.Thegainseemsequivalenttodelayedestrogen.In:Albertsson-WiklandK,RankeM,eds.Tu
3、rnerthatachievedwith1yearofGHtherapyalone.ASyndromeinaLife-spanPerspective.NewYork,NY:Amsterdam/NewYork;1995:175±181trialwithalargernumberofpatientswillberequired8.LiebermanS.Arethedifferencesbetweenestradiolandotherestrogens,toconfirmthesedataandtode
4、terminethelong-termnaturallyoccurringorsynthetic,merelysemantical?JClinEndocrinolconsequenceofthisinterventionstrategyonboneMetab.1996;81:850±853mineralization.9.JensenE,JacobsonH,FlesherJ,etal.Estrogenreceptorsintargettissues.In:NakaoT,PincusG,TaitJ,
5、eds.SteroidDynamics.NewYork,ACKNOWLEDGMENTSNY:AcademicPress;1966:133±15710.KorenmanS.ComparativebindingaffinityofestrogensanditsrelationThisstudywassupportedinpartbyUSPublicHealthServicetoestrogenicpotency.Steroids.1969;13:163±177GrantRR-00055toDrRose
6、nfieldandinpartbyGenentech,Inc,11.HiraiS,HussainA,HaddadinM,SmithR.First-passmetabolismofSouthSanFrancisco,CA(agrantofgrowthhormoneandstatis-ethinylestradiolindogsandrats.JPharmSci.1981;70:403±406ticalsupport).12.LauferL,DeFazioJ,LuJ,etal.Estrogenrepl
7、acementtherapybytransdermalestradioladministration.AmJObstetGynecol.1983;146:REFERENCES533±5401.RosenfieldRL,FangVS.Theeffectsofprolongedphysiologicestradiol13.ClemmonsD,UnderwoodL,RidgwayE,KlimanB,KjellbergR,Vantherapyonthematurationofhypogonadalteen
8、agers.JPediatr.1974;85:WykJ.Estradioltreatmentofacromegaly:reductionofimmunoreactive830±837somatomedin-Candimprovementofmetabolicstatus.AmJMed.1980;2.ZachmannM,PraderA,SobelE,etal.Pubertalgrowthinpatientswith69:571±575androgeninsensitivity:ind
