Attenuation Correction of SPECT Using X-Ray CT on an Emission-Transmission CT

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1、AttenuationCorrectionofSPECTUsingX-RayCTonanEmission-TransmissionCTSystem:MyocardialPerfusionAssessmentS.C.Blankespoor,X.Wu,K.Kalki,J.K.Brown,C.E.Cann,andB.H.HasegawaUniversityofCaliforniaatSanFranciscoAbstractTheSPECTimageisacquiredwithascintillationcamera.Imagemisregist

2、rationisminimizedbyplacingthetwoWepresentexperimentalresultsforattenuationcorrectionimagingscannersadjacenttooneanothersothattheemissionofemissiontomographythroughuseofanattenuationmapandtransmissionimagesareacquiredwithoutremovingthederivedfromX-rayCTdata.BoththeX-rayand

3、gamma-raypatientfromthetablebetweenthetwoscans.Wereportheredatawereobtainedonaprototypeemission-transmissiontheresultsobtainedusingthissystem,withitsattenuationimagingsystem(“X-SPECT”)whichincorporatesathird-correctioncapabilities,formyocardialperfusionassessmentgeneratio

4、nX-rayCTscannerandasingle-headedSPECTinpigs.scanner.ThetwocommercialimagingdevicesarejuxtaposedsuchthattheCTtablecanmovethepatient11.SYSTEMDESIGNdirectlyintotheSPECTscanneraftertheX-rayscan.ThisenablessystematicregistrationofSPECTandX-rayCTOurcombinedX-SPECTimagingsystemi

5、sshowninimages.Tocalibrateattenuationmapcreation,asetofCTFigure1.NotetheadjacentpositionsofthetwocommercialscansforaspecificphantomgeometryandX-raytechniquescanners.Thescannersshareasingletabletoprecludethewereacquired,withvaryingattenuatingmaterialsineachneedformovementb

6、ythepatientbetweenSPECTandX-rayscan.ApiecewiselinearfitwasappliedtotheCTnumbersCTscans.Registrationofimagesfromthetwomodalitiesisandknownattenuationcoefficientsat140keV,andtheresultsimplifiedbythesharedtableandknownsystemgeometry.isusedtocreateattenuationmapsat140keVfromg

7、ivenCTThejuxtapositionofourSPECTscannerandCTscannerimages.ThistechniquehasbeenappliedtosmallpigsinresultsintheexposureofourSPECTscannertoasignificantmyocardialperfusionstudies.CorrectingforattenuationfluxofscatterfromtheCTscanner.Wehave,however,increasedtheimage-derivedmy

8、ocardialradionuclidemeasuredthisscatterfluxunderextremeX-rayCToperatingconcentrationvaluesfrom16