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1、ReviewArticleJournalofCosmeticDermatology,11,134143EffectsofSolarRadiationontheSkin1223ThomasGPolefka,PhD,ThomasAMeyer,PhD,PatriciaPAgin,PhD,&RobertJBianchini,PhD1LifeSciencesSolutions,LLC,Somerset,NewJersey,USA2MerckConsumerCare,Memphis,Tennessee,USA3MerckConsumerCare,Summit,NewJersey,USASummaryNo
2、onewouldunderestimatetheimportanceofsunlighttotheevolutionoflifeontheearthanditsroleinhumandevelopment.However,allhumansespeciallyindividualswhoarelightlypigmentedorwhoseoccupationorlifestyleexposesthemtoexcessiveamountsofsunlightarepotentiallysusceptibletoitsdeleteriouseffects.Theseeffectscanrange
3、fromacutebiologicalresponses,suchassunburnandskintanning,toconditionsresultingfromchronicexposuresuchasphotoagedskinandpotentiallylife-threateningconditionssuchasskincancer.Theobjectiveofthisreviewistopresentaconciseandup-to-dateperspectiveontheeffectsofUVB,UVA,visible,andinfraredradiationoncutaneo
4、usbiochemistryandphysiology.Keywords:antioxidants,freeradicals,infrared,oxidativestress,skin,sunprotection,sunlight,UV,visibleAccordingtoIchihashietal.,approximately6%oftheIntroductionsolarspectrumisUVR(k200400nm),52%isvisibleSincetheformationoftheearth10billionyearsago,light(k400760nm),andtherema
5、ining42%isIR67thesunhasplayedavitalroleintheevolutionoflifeon(k76010nm).1theearth.Formosthumans,thesunsradiantenergyisFromahealthperspective,radiationintheultravioletamixedblessing.Formany,itprovidesapsychologicalregionisofparticularrelevance.Accordingtotheliftandanopportunitytomodify,albeittempora
6、rily,InternationalCommissiononIllumination,ultraviolettheirskincoloration(i.e.,Caucasians)andtogenerateradiation(UVR)isdividedintothreecomponents:UVC2vitaminD.Toothers,occupationalandorrecreational(100290nm),UVB(290320nm),andUVA(3208exposurecanleadtoacceleratedskinaging(i.e.,400nm).Fortunately,them
7、ostenergeticformofUVR,3,4photoaging)andcarcinogenesis.RegardlessoftheUVC(100290nm)doesnotreachgroundlevelbecausereason,excessiveexposuretosunlightisamajorriskitiseffectivelyabsorbedbythestratosphericozone59
