阻塞性睡眠呼吸暂停低通气综合征对左心室肥厚的影响

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1、阻塞性睡眠呼吸暂停低通气综合征对左心室肥厚的影响3．统计学分析数据应用SPSSl1．5forWindows统计处理。根据资料和设计类型的不同分别采用单因素方差分析，两独立样本t检验，线性相关分析及多元逐步回归分析。以P<0．05认为差异有统计学意义。结果1．对照组ⅣSd、LVPWd、LVMI均低于研究组，而EH+OSAHS组的ⅣSd、LvPWd、LVMI又分别高于EH组及OSAHS组(P0．05)。3．分别以IVSd、LVPWd、LV

2、MI为因变量，AHI、LSa02、SBP、DBP、BMI为自变量，逐步回归法回归分析，发现入选回归方程的变量只有AHI、SBP。说明AHI、SBP是影响IVSd、LvPWd、LVMI的独立危险因素。4．将52例OSAHS患者分为轻度OSAHS组(30例)及中重度OSAHS组(22例)两组间比较得出：中重度OSAHS组的SBP、DBP及BMI显著高于轻度OSAHS组；0SAHS与血压的相关性分析显示：AHI与SBP、DBP成正相关，而LSa02与SBP、DBP成负相关。结论1．0SAHS是导致左心室肥厚的独立危险因素，高血压及OSAHS均可能导致左心室肥厚，高血压合并OSAHS对左心室肥厚的影

3、响高于其各自对左心室肥厚的影响。2．0SAHS可能是引起原发性高血压的因素之一。关键词：阻塞性睡眠呼吸暂停低通气综合征，左心室肥厚，高血压阻塞性睡眠呼吸暂停低通气综合征对左心室肥厚的影响Impactofobstructivesleepapnea—hypopneasyndromeonleftventricularhypertrophyMajor：OtorhinolaryngologyName：LongChao—QingSupervisor：Prof．ZouHuaABSTRACTBACKGRoUNDANDOBJECTⅣEObstructivesleepapnea-hypopneasyndrome

4、(OSAHS)isadisorderofbreathingduringsleepcharacterizedbyrepetitivecollapseoftheupperairway,accompaniedwithrepeatedsleepapneaandhypopnea,snoring，episodesofhypoxia．Asrepeatedhypoxia,hypercapniaanddisorderofsleep，OSAHSmayleadtomanycomplications，especiallycardiovascularcomplications，whichbadlyinfluencet

5、hepatient’Squalityoflife．Repeatedhypoxia,hypercapnia,changesofintra-thoracicpressure，hemodynamicsandncurocndcrine，whichhappenedfrequentlyinOSAHS，alecloselycorrelatedtothedevelopmentofcardiovasculardiseases．OSAHSisanindependentriskfactorofessentialhypertension(EH)，anditplaysasignificantpartincoronar

6、yarterydisease，type2diabetesmellitus，cerebrovasculardisease．However，therelationshipbetweenOSAHSandleftventricularhypertrophy(LVH)iscontroversial．TherearestudiesfoundthatOSAHSwasanindependentriskfactorofLVHbesideshypertension,butsomestudiesboldthecontradictiveview．Therearestillnoinvestigationaboutth

7、erelationbetweenOSAHSandLVHinourcountry．FurtherstudyneedstodotoconcludewhetherOSAHSisanindependentriskfactorofLVH．ThepurposeofthisstudyistoapproachtheimpactofOSAHSonLVH，toseev阻塞性睡眠呼吸暂停低通气综合征对左心室肥厚的影响whether