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1、中文摘要多功能纳米粒子的设计合成及在生物上的应用大提高。（4）多功能纳米粒子Au-Fe3O4的合成及在磁共振和CT成像方面的应用。通过热分解法在Au纳米粒子表面长上磁性四氧化三铁纳米粒子。磁共振和CT成像结果显示，该复合材料不仅具有磁性四氧化三铁纳米粒子的磁共振造影效果，而且具有CT造影效果，并且低浓度Au-Fe3O4造影剂在兔子体内造影模型中获得了与高浓度碘剂同样的强化效果，同时具有明显的磁共振造影增强效果。该研究表明，Au-Fe3O4是一种制备简单、效果优异的双模式显像剂。关键词：四氧化三铁；磁共振成像；靶向；CT；硫化铋；纳米棒；多功能造影剂；生物作者：鲁英杰指导老师：顾宏伟IID
2、esign,SynthesisandBiomedicalApplicationsOfMultifunctionalNanoparticlesAbstractDesign,SynthesisandBiomedicalApplicationsOfMultifunctionalNanoparticlesAbstractNanomaterialspresentspecialcharacteristicswhichconventionalmaterialsdonotpossess,forexample,quantumsizeeffect,smallsizeeffect,surfaceeffecta
3、ndthemacroscopicquantumtunneleffectetc.Thereforenanomaterialshaveawiderangeofapplicationprospectsinfieldssuchasmagneticmaterials,opticalmaterials,electronicmaterials,sensingmaterials,catalysisandbiomedicalscienceetc.Inthispaper,wesynthesizedaseriesofuniformsizenanostructures,suchasFe3O4nanopartic
4、les,Pt@Fe2O3nanorods,Bi2S3andBi2S3-Aunanorods,Au-Fe3O4nanoparticles.Theshapesandcrystalstructuresofnanoparticleswerecharacterizedbytransmissionelectronmicroscope(TEM),X-raydiffraction(XRD),highresolutiontransmissionelectronmicroscope(HRTEM),energydispersionX-rayanalysis(EDS)andsoon.Someofthesemat
5、erialsweremodifiedandthenstudiedinbiologicalimagingapplications.Themainworkincludesthefollowingaspects:(1)FolatereceptortargetedironoxidenanocompositesforhepaticcarcinomaMRimaging.Themagneticironoxidenanoparticlesweresynthesizedbythermaldecompositionmethodwithanaveragesizeof~14nmandnarrowmolecula
6、rweightdistribution,andthenmodifiedbyhydrophilicdextranandfolicacid,somagneticoxideofironnanoparticleswithcancercelltargetingfunctionwereobtainedwhichhavetheadvantagesofsmallersize,hydrophilic,excellentdispersionandlowcytotoxic.Folatetargetednanocomposites(IONP-DA-dextran-FA),whicharenontoxic,fav
7、orablebiocompatibility,andexcellentsignal,werebeendemonstratedtohavethepotentialappliacationsinMRIcontrastenhancementeffectsinvitroandvivoforanimals.(2)MagneticFe2O3nanorodswithlowcelltoxicityweresuccessfullysynthesize
