干扰βTC-3细胞上胰岛素受体表达对胰岛素一相分泌的影响

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1、分类号密级国际十进分类号（UDC）第四军医大学学位论文干扰βTC-3细胞上胰岛素受体表达对胰岛素一相分泌的影响（题名和副题名）马丽芬（作者姓名）指导教师姓名焦凯教授（主任医师）指导教师单位第四军医大学唐都医院内分泌科申请学位级别硕士专业名称内科学（内分泌学）论文提交日期2008.04答辩日期2008.05论文起止时间2006年07月至2008年05月学位授予单位第四军医大学独创性声明秉承学校严谨的学风与优良的科学道德，本人声明所呈交的论文是我个人在导师指导下进行的研究工作及取得的研究成果。尽我所知，除了文中特别加以标注和致谢的地方外

2、，论文中不包含其他人已经发表或撰写过的研究成果，不包含本人或他人已申请学位或其他用途使用过的成果。与我一同工作的同志对本研究所做的任何贡献均已在论文中作了明确的说明并表示了致谢。申请学位论文与资料若有不实之处，本人承担一切相关责任。论文作者签名：日期：保护知识产权声明本人完全了解第四军医大学有关保护知识产权的规定，即：研究生在校攻读学位期间论文工作的知识产权单位属第四军医大学。本人保证毕业离校后，发表论文或使用论文工作成果时署名单位仍然为第四军医大学。学校可以公布论文的全部或部分内容（含电子版，保密内容除外），可以采用影印，缩印或其

3、他复制手段保存论文。学校有权允许论文被查阅和借阅，并在校园网上提供论文内容的浏览和下载服务。论文作者签名：导师签名：日期：干扰βTC-3细胞上胰岛素受体表达对胰岛素一相分泌的影响研究生：马丽芬学科专业：内科学（内分泌学）所在单位：第四军医大学唐都医院内分泌科导师：焦凯教授（主任医师）关键词：胰岛素受体；siRNA；RNA干扰；转染；胰岛素一相分泌中国人民解放军第四军医大学2008年05月第四军医大学硕士学位论文目录缩略语表························································

4、······················································1中文摘要··············································································································4英文摘要·······························································································

5、···············7前言及文献回顾································································································100引言···············································································································101胰岛素受体的结构及分型····················

6、························································112细胞是胰岛素作用的靶细胞········································································113β细胞上的胰岛素信号系统···········································································124胰岛β细胞上胰岛素受体的功能···················

7、··········································134.1葡萄糖刺激的胰岛β细胞分泌反应················································134.2胰岛素刺激的胰岛β细胞分泌反应················································154.3胰岛素与葡萄糖·············································································16

8、5RNAi（RNAinterference）······································································165.1RNAi的作用机制···········