Ⅲ期乳腺癌锁骨上淋巴结清扫的临床意义

《Ⅲ期乳腺癌锁骨上淋巴结清扫的临床意义》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、中文摘要20．881)。2生存曲线提示手术组和对照扫组3年DFS、OS均有统计学意义(p

2、术不能提高IIIC期乳腺癌患者DFS、OS，而且手术后患侧上肢淋巴水肿发生率较单纯锁骨上区放疗者高，故对于IIIC期乳腺癌患者锁骨上淋巴结清扫术是不必要的。2组织学分级、脉管瘤栓、家族史、分子生物分型是影响IIIC期乳腺癌患者预后的因素。3本研究提示新辅助化疗并不能改善IIIC期乳腺癌患者DFS、OS，此结果与国内外一些研究类似。4本组数据是基于河北医科大学第四医院现有的病历资料做出的，存在选择偏倚、失访偏倚等，所以结果有待于更长的随访时间、更广泛的资料。关键词：乳腺癌；锁骨上淋巴结清扫术；新辅助化疗；组织学分级；脉管瘤栓；分子生物分型；遗传因素

3、荚文摘要TheclinicalsignificanceofsupracIaVicularlymphnodedissectionforstageIIICbreastcancerABSTRACTObjective：Accordingtothe2002editionoftheAJCC’STNMstagingsystemforbreastcancer，supraclavicularlymphnodemetastasiswasclassifiedtolocalregionallymphnodemetastasis，andcomprehensivetreat

4、mentcanimprovetheprognosis．TheobjectiveofthisstudywastoevaluatetheclinicalsignificanceofsupraclavicularlymphnodedissectionforstageIIICbreastCanCer．Methods：Atotalof162patientsofstageIIICbreastcancerfromFourthHospitalofHeibeiMedicalUniversitywereretrospectivelyanalyzed．Allofthe

5、patientsreceivedthetreatmentintheperiodof2010—01to2011．12．Thepatientsweredividedintotwogroupsaccordingtothedifferenttreatmentforsupraclavicularregion．Operationgroup：supraclavicularlymphnodesurgery+radiotherapyofsupraclavicularregion，37patients，themedianagewas47year-old(27—74y

6、ear—old)；controlgroup：radiotherapyofsupraclavicularregion，125patients，themedianageWas54year-old(32—79year-old)．Allpatientswerefollowedupto2013—11，Themedianoffollow．uptimewas33months(4—46months)．AunivariateanalysisandmultivariableCoxregressionmodelandzetheprognosticfactorsfors

7、tageIIICbreastcancer，includingsurgery，age，menopausalstatus，细mlyhistory，concomitant，neoadjuvantchemotherapy，histologicalgrade，numberofpositivelymphnodes，lymphovascularinvasion，andmoleculartyping．Results：1Follow-upResults．1．1Among162casesofstageIIICbreastcancerpatients，therewer

8、e84casesappeareddisease—freesurvival，and101casesappearedsurvivalwith