资源描述：
《Heaves, an asthma-like disease of horsesresp_2033 1027..1046英文资料》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、INVITEDREVIEWSERIES:CUTTINGEDGETECHNOLOGIESSERIESEDITOR:DARRYLKNIGHTHeaves,anasthma-likediseaseofhorsesresp_20331027..1046MATHILDELECLERE,*ANOUKLAVOIE-LAMOUREUX*ANDJEAN-PIERRELAVOIEDepartmentofClinicalSciences,FacultyofVeterinaryMedicine,Universitéde
2、Montréal,St-Hyacinthe,CanadarelevanttoasthmaincludetheroleofneutrophilsinABSTRACTairwayinflammationandtheirresponsetocorticos-Animalmodelshavebeendevelopedtoinvestigateteroids,systemicresponsetopulmonaryinflamma-specificcomponentsofasthmaticairwayinflamm
3、a-tion,andmaintainingathleticcapacitieswithearlytion,hyper-responsivenessorremodelling.However,intervention.alloftheseaspectsarerarelyobservedinthesameanimal.HeavesisanaturallyoccurringdiseaseofKeywords:animalmodel,asthma,inflammation,horsesthatcombin
4、esthesefeatures.Itischaracter-remodelling.izedbystabledust-inducedinflammation,broncho-spasmandremodelling.TheevaluationofhorsesINTRODUCTIONANDDEFINITIONduringwell-controllednaturalantigenexposureandavoidanceinexperimentalsettingsallowsthestudyofdisea
5、semechanismsintheasymptomaticandsymp-Inthepastdecades,muchhasbeenlearnedonthetomaticstages,anapproachrarelyfeasibleinpathophysiologyofasthmafromthestudyofhumanhumans.Also,thediseasecanbefollowedoverseveralpatientsandanimalmodels.Geneandenvironmentyea
6、rstoobservethecumulativeeffectofrepeatedepi-interactions,whichvarybasedonthetypeanddura-sodesofclinicalexacerbationortoevaluatelong-termtionofantigenexposureaswellasothertriggeringtreatment,contrastingmostmurineasthmamodels.events,havebeenhighlighted
7、.ManyofthesecomplexThismodelhasshowncomplexgeneandenvironmenteventsaredifficulttomodelinrodents.Equineheavesinteractions,theinvolvementofbothinnateandisaspontaneousoccurringasthma-likeconditionadaptiveresponsestoinflammation,andthecontri-affectingadome
8、sticanimalspecies.Inthisreview,butionofbronchospasmandtissueremodellingtowewilldescribethecharacteristicfeaturesofheavesairwayobstruction,alloccurringinanaturalsetting.andhighlightnovelfindingsparticularlyrelevanttoSimilaritieswiththehumanasthmaticair
