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1、JournalofControlledRelease160(2012)409–417ContentslistsavailableatSciVerseScienceDirectJournalofControlledReleasejournalhomepage:www.elsevier.com/locate/jconrelProtocolpaperDesign,productionandoptimizationofsolidlipidmicroparticles(SLM)byacoaxialmicrofluid
2、icdevicea,1b,1b,⁎LorenzoCapretto,StefaniaMazzitelli,ClaudioNastruzziaEngineeringSciences,FacultyofEngineeringandtheEnvironment,UniversityofSouthampton,UniversityRoad,SouthamptonSO171BJ,UKbDepartmentofLifeSciencesandBiotechnology,UniversityofFerrara,ViaFos
3、satodiMortara17/19,Ferrara,44121,ItalyarticleinfoabstractArticlehistory:Thispaperdescribesamethodfortheproductionoflipidmicroparticles(SLM)basedonmicrofluidicsusingaReceived21December2011newlydesignedmodulardeviceconstitutedofthreemainparts:atemperaturecon
4、trol,aco-flowdrippingAccepted10April2012elementandacongealingelement.ThepresenteddatademonstratedthatthemicrofluidicapproachresultedAvailableonline19April2012intheproductionofSLMwithnarrowsizedistributionandoptimalmorphologicalcharacteristicsintermofspheric
5、ity,surfacesmoothnessandabsenceofdefects(i.e.partialcoalescenceorirregularshape).Theopti-Keywords:mizationofSLMproductionwasperformedbyscreeningtheeffectofdifferentexperimentalparametersCoaxialflowMicrofluidicsanddeviceconfigurationsbyaclassicalintuitiveappr
6、oachCOST(ChangingOneSeparatefactoraTime).SolidlipidmicroparticlesThisprocessallowedselectingthepropervalueforanumberofparametersincluding,(i)thecongealingel-ementgeometry,(ii)thepresenceandconcentrationofastabilizer,(iii)thetemperatureofwaterandoilphasesa
7、nd(iv)thewaterandoilflowrates.Inaddition,theinterplaybetweenoilphaseandwaterphaseflowrates,incontrollingthesizeandmorphologyofSLM,wasinvestigatedbyastatistical“DesignoftheEx-periments”approach(DoE).ThecombineduseofCOSTandDoEstudiesallowedtheproductionofopti
8、mizedSLMfortheencapsulationofdye/drugs.TheobtainedresultsdemonstratedthattheguestmoleculesdidnotaffectthegeneralcharacteristicsofSLM,confirmingtherobustnessofthemicrofluidicprocedureinviewoftheproductionofSLMforbiopha
