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1、现代医院2010年4月第10卷第4期专业技术篇ModernHospitalApr2010Vol10No426新生儿高胆红素血症心肌酶谱与超敏C-反应蛋白的临床意义赵璇珠李玲黄晓东CLINICALSIGNIFICANCEOFMYOCARDIALENZYMESANDHIGHSENSITIVITYC-REACTIVEPROTEININNEONATALHYPERBILIRUBINEMIAZHAOXuanzhu,LILing,HUANGXiaodong【摘要】目的探讨新生儿高胆红素血症患儿心肌酶谱及超敏C-反应蛋白改变的临床意义。方法
2、选取2007年1月～2009年10月,我院收治的90例足月新生儿,高胆红素组60例,对照组(正常新生儿)30例,高胆红素组治疗前、后及对照组均行股静脉穿刺采血作肝功能、心肌酶谱(CK、CK-MB、LDH、AST)及hs-CRP检测。结果高胆红素组治疗前心肌酶谱及超敏C-反应蛋白浓度与对照组比较明显升高,差异有统计学意义(p<0.01);高胆红素组治疗后心肌酶谱及超敏C反应蛋白浓度趋于正常(p>0.05);治疗前后有非常显著性差异(p<0.01)。结论新生儿高胆红素血症可发生心肌损害,早期心肌酶谱与超敏C-反应蛋白测定有助发现
3、其心肌损害,具有临床指导意义。【关键词】心肌酶谱超敏C-反应蛋白心肌损害新生儿高胆红素血症【Abstract】ObjectiveToanalyzetheclinicalsignificanceofmyocardialenzymesandhighsensitivityC-re-activeprotein(hsCRP)inneonatalhyperbilirubinemia.Methods90casesoffull-termnewbonesintheperiodfromJanuary2007toOctober2009atourh
4、ospitalweredetermined.Thehepaticfunctiontest,myocardialenzymes(CK,CK-MB,LDH,AST)andhsCRPwereassayedin60casesofneonatalhyperbilirubinemiabothinprior-treatmentandpost-treatment,andin30casesofhealthynewbornsviafemoralveinpuncture.ResultsThelevelofmyocardialenzymesandh
5、sCRPwereobviouslyincreasedinthegroupofhyperbilirubinemiacomparedwiththegroupofhealthynewborns(p<0.01)andweregraduallytendedtobenormallevelaftertreatment.ThelevelofmyocardialenzymesandhsCRPhadsignificantdifferencebetweenprior-treatmentandpost-treatmentinneonatalhype
6、rbiliru-binemia(p<0.01).ConclusionMyocardialinjurycanoccurinneonatalhyperbilirubinemia.TheearlydetectionofmyocardialenzymesandhsCRPcanbeusedasavaluablemonitoringindexinclinicalpractice.【Keywords】Myocardialenzymes,HighsensitivityC-reactiveprotein,Myocardialinjury,Ne
7、onatalhyper-bilirubinemia【Author′saddress】ZhuchiHospitalofLonghuDistrict,ShantouCity,GuangdongProvince515041PRCdoi:10.3969/j.issn.1671-332X.2010.04.011新生儿高胆红素血症是新生儿的常见疾病之一。美国治确诊的新生儿高胆红素血症60例(高胆红素组),均为足CUBEMICK报道:正常足月新生儿高胆红素血症发生率为月新生儿,全部病例均符合新生儿高胆红素血症的诊断标[1][6]60%,早
8、产儿达80%。部分新生儿高胆红素血症可致中准,血清总胆红素≥205.2μmol/L,其中男47例,女41枢神经系统损害,产生胆红素脑病。近年来,随着胆红素生例;日龄2～28d,平均5.8±4.0d,胎龄37～41w,平均胎龄理功能及毒性的进一步研究,发现胆红素对心脏、肾脏等多38.8±0.
