Asymmetric ruthenium (Ⅱ ) Complexes of DNA Synthesis and Mode of Study

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1、Asymmetricruthenium(Ⅱ)ComplexesofDNASynthesisandModeofStudyAuthor:tubeXiao-Yan,LiuJun,HeLi-Xin,Lu,HomeEconomics,Wen-JieMei[Abstract]Objectiveandmethodsofsynthesisofanewruthenium(Ⅱ)polypyridinecomplexes[Ru(4,7dmp)2(PYNI)](ClO4)2[4,7dmp=4,72-methyl1,10phe

2、nanthroline,PYNI=2(2‘pyridine)naphthylimidazole],usingelementalanalysis,electrospraymassspectrometry,nuclearmagneticresonancespectraofthecomplexeswerecharacterizedby;electronicabsorptionspectra,fluorescencespectra,viscosity,meltingpointdeterminationofDNAte

3、stingandresearchoftheroleofthecomplexwithDNA.ResultsandConclusioncomplexes[Ru(4,7dmp)2(PYNI)](ClO4)2andtheDNAbyinsertingbetweenthemodeofbinding.[Keywords:]ruthenium(Ⅱ)complexes;DNA;spectralproperties;viscositytestAbstract:ObjectiveandMethodsAnewRuthenium(Ⅱ)

4、polypyridylcomplex[Ru(4,7dmp)2(PYNI)](ClO4)2[4,7dmp=4,7dimethyl1,10phenanthroline,PYNI14=2(2‘pyridyl)naphthoimidazoimidazole)]hasbeensynthesizedandcharacterizedbyelementalanalysis,ESMSand1HNMR.TheDNAbindingbehaviorswereinvestigatedbyelectronicabsor

5、ptionspectroscopy,fluorescentspectroscopy,viscositymeasurementandDNAmeltingexperiment.ResultsandConclusionTheresultsshowedthecomplex[Ru(4,7dmp)2(PYNI)]2bindingtoDNAthroughintercalationmode.Keywords::ruthenium(Ru)complex;DNA;spectralproperties;viscositymeasu

6、rementInrecentyears,peoplearesmallmoleculesoftransitionmetalpolypyridylcomplexeswithDNAmacromoleculesgraduallyin-depthstudyoftheinteraction,thisresearchhasbecomeveryactiveinthefieldofbio-inorganicchemistrystudy.Octahedralpolypyridylrutheniummetalcomplexesand

7、theroleofDNAhasarousedgreatinterest[1,2],ascomparedwithothermetalcomplexes,suchcomplexesforbotheasytoconstructarigidbringschiraloctahedralconfiguration,andthethermodynamicstabilitycomplexes,photochemicalandphotophysicalinformation-rich,eitherasDNAstructuralp

8、robes[3],butalsocanserveasaDNAmolecularlightswitch,DNA-mediatedelectrontransfer,DNA14breakagereagent[4]andsoon.Studieshaveshownthatthesecomplexescaninsert,electrostaticandgroovetocoverthethreeki