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《炎性历程模拟体液对多孔HA_TCP生物陶瓷类骨磷灰石形成的影响》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。
1、生物医学工程学杂志JBiomedEng2004;21(4)∶531～535炎性历程模拟体液对多孔HA/-TCP*生物陶瓷类骨磷灰石形成的影响1,21,111季金苟冉均国苟立王芳瑚孙璐薇1(四川大学无机材料系,成都610065)2(重庆大学化学化工学院,重庆400044)摘要通过对多孔HA/-TCP生物陶瓷在炎性历程模拟体液(Simulatedbodyfluid,SBF)中动态浸泡(即先在模拟炎性体液pH6.5的SBF中动态浸泡2d,再在正常体液pH7.4的SBF中动态浸泡12d)的类骨磷灰石形成情况的研究后发现,模拟炎性历程的微酸性会溶解材料表面颗粒较细或曲率半径较小的部分,使材料表面变
2、得光滑和溶解性能下降,在随后正常体液的pH值下类骨磷灰石的形成量明显减少,这为理解钙磷生物陶瓷植入体内的诱导成骨机理和在体外筛选骨诱导性较好的钙磷材料提供了更可靠的方法。另外,实验结果还显示,用微波等离子体烧结的多孔HA/-TCP生物陶瓷,在正常SBF和模拟了炎性历程的SBF的动态实验中,其类骨磷灰石形成情况都好于用常规马弗炉烧结的样品,这预示用微波等离子体烧结的多孔HA/-TCP生物陶瓷可能具有更好的骨诱导活性。关键词多孔HA/-TCP生物陶瓷模拟炎性历程模拟体液类骨磷灰石TheEffectofASimulatedInflammationProcedureinSimulatedBody
3、FluidonBone-likeApatiteFormationonPorousHA/-TCPBioceramics1,21,111JiJingouRanJunguoGouLiWangFangfuSunLuwei1(DepartmentofInorganicMaterials,SichuanUniversity,Chengdu610065,China)2(CollegeofChemistryandChemicalEnineering,ChongqingUniversity,Chongqing400044,China)AbstractTheformationofbone-likeapatit
4、eonporousHA/-TCPbioceramicsindynamicsimulatedbodyfluid(SBF)undergoingasimulatedinflammationprocedure(pH=6.5)wasinvestigatedinordertostudythemechanismofosteoinductionandbuildanewmethodtochoosebiomaterialswithbetterbioactivity.TheresultsshowedthatthesurfaceofporousHA/-TCPbioceramicswhichunderwentasi
5、mulatedinflammationprocedureindynamicSBFwasmoresmooth.ThelightacidityinthesimulatedinflammationprocedurewoulddissolvethefinegrainsandthepartspossessingsmallercurvatureradiusonthesurfaceofporousHA/-TCPbioceramics,whichwouldreducethebioceramicssolubility.FollowedinnormalSBF(pH=7.4),theamountofbone-li
6、keapatiteformedontheporousHA/-TCPbioceramicswaslessthanthatofporousHA/-TCPbioceramicsincubationinnormalSBFallalong.Theresultsalsoshowedthattheamountofbone-likeapatiteformedontheporousHA/-TCPbioceramicssinteredbyamicrowaveplasmawasmorethanthatofporousHA/-TCPbioceramicssinteredbyaconventionalfurna
7、ce.KeywordsPorousHA/-TCPbioceramicsSimulatedinflammationprocedureSimulatedbodyfluidBone-likeapatite*国家重大基础研究项目资助(973G1999064701)联系人。Tel:028-85401280532生物医学工程学杂志第21卷了循环系统,让SBF以正常生理流率(2m1/min)流1引言动,因而
