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ID:32476951
大小:1.62 MB
页数:56页
时间:2019-02-07
《钙磷多孔生物陶瓷骨修复材料的制备》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、摘要钙磷多孔生物陶瓷具有良好的生物相容性,在骨修复领域得到广泛的研究和应用。为了降低磷酸钙多孔生物陶瓷的烧结温度,本研究采用有机泡沫浸渍法制备了I-IA/13-'rCP—CaC03-NaH2P04和H~口.TCP.(NaP03)#.Mg(H2P04)2两种陶瓷坯体,分别经900。C和850℃烧结得到多孔陶瓷。对陶瓷成型性能和基本力学性能的对比研究发现,后者的综合性能较好,因此,后续研究都围绕该体系进行。采用x射线衍射(Ⅺ①)、扫描电镜(sEM)、能谱(EDS)等方法对钙磷多孔生物陶瓷HA/p-TCP一(N
2、aP03)6-Mg(H2P04)2的组织、结构和性能进行了表征与测试。该多孔生物陶瓷在850℃即可烧结成型,具有良好三维连通的孔隙结构,孔径为200~5009m,孔隙率达81%,抗压强度为1.45MPa,主要由13-TCP、i3-ca2P207和CaO—MgO-Na20一P205磷酸盐玻璃组成。为提高钙磷多孔生物陶瓷的力学强度,分别采用明胶和PLLA涂覆对其进行增强处理。研究表明,明胶和PLLA涂覆均能提高支架的力学性能,而明胶涂覆效果更佳。对增强处理前后的多孔生物陶瓷进行了兔骨髓间充质干细胞体外细胞相容
3、性评价,涂覆前后的钙磷多孔生物陶瓷均无细胞毒性,明胶涂覆处理后陶瓷的生物相容性最好,PLLA涂覆处理后陶瓷的生物相容性较差。关键词:骨修复材料,钙磷陶瓷,烧结温度,增强处理,生物相容性AbstractPorouscalciumphosphatebioceramicspossessgDodbiocompatibilityandhavebeenstudiedandusedextensivelyinbonerepairing.TwokindsofporousceramicofHA/13-TCP·CaCOrNaH
4、2P04andI{』~/B—TCP一(NaP03)6-Mg(H2P04)2Werefabricatedbythepolyurethanepolymermethodandsinteredat900℃and850"C.respectively.Itwasshowedthatthelatteronewasbetterthantheformerintheaspectsofformabilityandbasicmechanicalproperty,SOthelatterwasfocusedinthefollowin
5、gresearchworks.nepropertiesofHA/p·TCP一(NaP03)6一Mg(H2P04hporousbioceranaiesWerecharacterizedandtestedbyXRD,SEM,EDS.Theporousceramicspossess3-Dwellinterconnectedporeswiththediameterof200to500“m,theporosity81%andcompressstrength1.45MPa.Afterbeingsintered,the
6、ceramicsWerecomposedof13-TCP,p-Ca2P207andCaO—MgO—Na20·P20sphosphateglass.Inordertoimprovethecompressives血engthoftheporousbioceramic,thegelatinandpolylaetideacid(PLLA)coatingswereusedforreinforcingtreatment,respectively.ItWasshowedthatthecoatingtreatmentof
7、bothgelatinandPLLACanincreasethecompressivestrengthofporousscaffoldsmarkedly,andthebetterresulthappenedwhengelatinused.Theporous,bioceramicsbothbeforeandaftertreated,donotexhibitcelltoxicitywhenevaluatedbyeO—culturewithrabbitbonemarrowmesenchymalstemcells
8、(BMSCs)invitro.Intheviewofbiocompatibility,thegelatincoatingWasthebestandthePLLAcoatingWastheworst.Keywords:bonerepairingmaterials,calciumphosphateceramics,sinteringtemperature,reinforcingtreatment,biocompatibilityⅡ
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