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1、2012年4月护理学报April,201210第19卷第4A期JournalofNursing(China)Vol.19No.4A【研究生园地·论著】4种漱口液对铜绿假单胞菌抑制效果的实验研究徐丽丽11211,王国权,何君,吴琼,范静(1.安徽医科大学解放军307医院临床学院,安徽合肥230032;2.军事医学科学院病原微生物安全国家重点实验室,北京100071)[摘要]目的探讨4种漱口液对铜绿假单胞菌的抑制效果,为肿瘤放化疗合并口腔铜绿假单胞菌感染患者更有针对性地选择漱口液提供依据。方法实验以铜绿假单胞菌为研究对象,将其分成实验组和
2、对照组,实验组采用临床常用4种漱口液:0.5%聚维酮碘溶液、0.02%醋酸氯己定溶液、复方氯己定含漱液、0.1%西吡氯铵含漱液,对照组采用生理盐水,观察4种漱口液的抑菌效果。结果在不同时间点上4种漱口液的抑菌效果均不相同,差异均有统计意义(P<0.05)。实验组4种漱口液作用后的活菌数量与对照组比较差异均有统计学意义(P<0.05);其中,实验组0.5%聚维酮碘溶液作用后的活菌数量明显低于其他3种漱口液,差异有统计学意义(P<0.05)。结论0.5%聚维酮碘溶液、0.02%醋酸氯己定溶液、复方氯己定含漱液、0.1%西吡氯铵含漱液4种漱
3、口液对铜绿假单胞菌均有抑制作用,其中0.5%聚维酮碘溶液的抑菌效果最明显。[关键词]漱口液;铜绿假单胞菌;抑菌效果[中图分类号]R472[文献标识码]A[文章编号]1008-9969(2012)04A-0010-03BacteriostaticEffectofDifferentGarglesonPseudomonasAeruginosainMouthXULi-li1,WANGGuo-quan1,HEJun2,WUQiong1,FANJing1(1.ClinicalSchoolNo.307HospitalofPLA,AnhuiMedic
4、alUniversity,Hefei230000,China;2.StateKeyLaboratoryofPathogenicMicrobeandBiosecurity,AcademyofMilitaryMedicalSciences,Beijing100071,China)Abstract:ObjectiveToexplorethebacteriostaticeffectofdifferentgarglesonpseudomonasaeruginosainthemouth,andtoprovidebasisforselectingc
5、orrespondinggargleandimprovethequalityoforalnursing.MethodsPseudomonasaeruginosawaschosenastheresearchsubjectinthisexperiment,whichincludedexperimentgroupsandthecontrolgroup.Inexperimentgroups,the0.5%povidone-iodinesolution,0.02%chlorhexidineacetatesolution,compoundchlo
6、rhexidinemouthwashand0.1%cetylpyridiniumchloridegarglewereappliedrespectively,whileincontrolgroup,thephysiologicalsalinewasused.Theantibacterialeffectsoffourgargleliquidswereobserved.ResultsTheantibacterialeffectsofdifferentmouthwashesindicatedstatisticaldifferencesatdi
7、fferenttime(P<0.05).Thenumberofviableinexperimentgroupswassignificantlylowerthanthatincontrolgroup(P<0.05).Inthegroupwiththe0.5%povidone-iodinesolution,thenumberofviablewassignificantlylowerthanthoseingroupswithotherthreekindsofmouthwashes(P<0.05).ConclusionFourkindsofg
8、argleliquidsinexperimentgroupsallhaveantibacterialeffectsonpseudomonasaeruginosawithinoralhygiene.Comparedwith