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1、Biosci.Biotechnol.Biochem.,71(3),735–740,2007InhibitionofIncreasesinBloodGlucoseandSerumNeutralFatbyMomordicacharantiaSaponinFraction1112YuichiOISHI,TatsuakiSAKAMOTO,HaruhideUDAGAWA,HironobuTANIGUCHI,131;yKazuoKOBAYASHI-HATTORI,YoshioOZAWA,andToshichikaTAKITA1DepartmentofNutritionalScienc
2、e,FacultyofAppliedBioscience,TokyoUniversityofAgriculture,1-1-1Sakuragaoka,Setagaya-ku,Tokyo156-8502,Japan2DepartmentofNutritionalScienceandCulinaryArts,ToitaWoman’sCollege,2-21-17Shiba,Minato-ku,Tokyo105-0014,Japan3DepartmentofHealthandNutrition,TakasakiUniversityofHealthandWelfare,37-1N
3、akaoruimachi,Takasaki,Gunma370-0033,JapanReceivedOctober17,2006;AcceptedDecember11,2006;OnlinePublication,March7,2007[doi:10.1271/bbb.60570]FocusingonafunctionalcomponentofMomordicapromotionofexercise,theusefulnessoffunctionalfoodscharantia,saponin,weinvestigateditseffectsonserumindailylif
4、eforthepreventionofdiabetesisrecognized.glucoseandneutralfatlevels.SaponinwasextractedasForthispurpose,studiesoffunctionalfoodcomponentsabutanol-solublefraction(saponinfraction)fromhotwithbloodglucose-controllingandserumlipid-loweringblast-driedMomordicacharantiapowder.Thedisac-effectsarei
5、nprogress,andmanyusefulcomponentscharidase-inhibitoryactivityandthepancreaticlipase-havebeendiscoveredinplants.inhibitoryactivityofthesaponinfractionweremeas-Momordicacharantia(MC)belongstothegourdfam-ured,andinvivosugar-andlipid-loadingtestswereilyandiswidelydistributedinAsia,EastAfrica,
6、andperformed.Thesaponinfractioninhibiteddisacchar-SouthAmerica.Ithasauniquebittertaste,andhasbeenidaseactivityandelevationofthebloodglucoselevelusedinfolkremediesfordiabetesforalongtime.2,3)aftersucroseloading.ThefractionalsomarkedlyFunctionalstudieshaveconfirmedtheanti-diabeticef-inhibite
7、dpancreaticlipaseactivityandelevationofthefectofMC,andbloodglucose-andserumlipid-loweringserumneutralfatlevelaftercornoilloading.BasedoneffectsofMCinSTZ-induceddiabeticratshavealsothesefindings,themainactivecomponentrelatedtothebeenreported.4)Astheactionmechanismofthe
