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时间:2019-05-24
《神经母细胞瘤规范化诊治的初步经验》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、万方数据452中华4,JL夕F科杂志2008年8月第29卷第8期ChinJPediatrSurg,August2008,V01.29,No.8·小儿肿瘤的相关研究·神经母细胞瘤规范化诊治的初步经验董岿然李凯高解春吕志葆肖现民【摘要】目的总结按日本研究会方案治疗神经母细胞瘤的经验体会。方法2000年至2006年间诊治新发/bJb神经母细胞瘤98例,年龄12d~144个月,经影像学、24h尿香革扁桃酸、骨穿和手术病理确诊。按INSS分期,I期3例、II期13例、III期31例、IV期48例、IVs期3例。治疗方案按日本研究会神经母细胞瘤综合治疗方案98年修订
2、版进行。结果本组术前新辅助化疗缓解率为49.2%(29/59),手术肉眼完整切除率为60.8%。总体2年生存率为73.4%,总体5年生存率为47.8%,其中III期分别为75.o%和58.8%,IV期分别为64.1%和20.()%。结论规范化治疗是提高神经母细胞瘤治疗效果的重要手段。Et本研究会方案是较为可行的方案之一,可有效提高患儿的生存率。肿瘤肉眼完整切除是神经母细胞瘤综合治疗的重要部分,外科医师参与并掌握治疗方案,是规范化治疗得以执行的保证。【关键词】神经母细胞瘤;多种化学疗法;外科手术Treatmentresultsofneuroblastoma
3、withastandardizationprotocolDONGKui-ran,LIKai,GAOJiPchun,LU么hi—bao,XJAoXian—ruing.DepartmentofSurgery,ChildrerrsHospitalofFudanU-niversity,Shanghai200032,China[Abstract]ObjectiveTosummarizeourexperienceonthetreatmentofneuroblastomaonthebasisoftheJapaneseStudyGroupProtoc01.Methods
4、Ninety-eightnewlydiagnosedpatientswithneu—roblastomawereincludedinthisstudyfromJanuary2000toDecember2006.Theageofthepatientswasfrom12daysto144months.Thediagnosiswasmadebyimageology,quantizationofurineVMAfor24hours,bonemarrowbiopsyandpostoperativepathologicaldiagnosis.Thestagingof
5、patientswasdeterminedbyINSSsystemasfollows:3casesinstageI,13inII,31jnIII,48inIVand3inIVs.ThetreatmentschemewasonthebasisoftheJapanesestudygroupprotocolwhichwasmodifiedin1998.ResultsTheremissionrateafterthenewassistantchemotherapywas49.2%.Grosstotalrsectionrateofthisgroupwas60.8%.
6、Theoverallsurvivalratesof2and5yearsinthisgroupwere73.4%and47.8%respectively.Amongthetotaloftheabove-mentioned,survivalratesofpatientsinstage111were75%and58.8%respectively,andthatinstageIVwere64.1%and20%respectively.ConclusionsStandardizedtreatmentiSanimportantwaytoimprovethesurvi
7、valrateofneuroblasto-ma.Japanesestudygroupprotocolmaybeofsignificantvalueinincreasingtheremissionrate.Sincegrosstotalresectionofthetumortakesanimportantroleintheneuroblastornatreatment,surgeonsshouldjoinintheclinicalpracticeofthepolychemotherapyandmasterthewholeprotoc01.[:Keyword
8、s]Neuroblastoma;Polychemotherapy;Surgica
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