欢迎来到天天文库
浏览记录
ID:38180579
大小:502.36 KB
页数:5页
时间:2019-06-03
《卡氏肺孢子菌肺炎的诊断治疗分析》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、万方数据1146中国人兽共患病学报ChineseJournalofZoonoses2011。27(12)文章编号:1002—2694(2011)12—1146—05卡氏肺孢子菌肺炎的诊断治疗分析林明,林晟,陈愉生,李鸿茹摘要:目的分析探讨卡氏肺孢子菌肺炎的早期诊断和治疗。方法分析福建省立医院2010年5月一2011年4月收治的曾误诊为细菌性肺炎的8例卡氏肺孢子菌肺炎病例的诊治。结果8例中3例为风湿免疫性疾病患者,1例为风湿性心脏病二尖瓣换瓣术后10年。其余4例无基础疾病。8例中,外院就诊均误诊为细菌性肺炎,误诊率100%,误诊时问I~6
2、个月。表现为反复发热,刺激样干咳、气促,病情进展快,出现不同程度呼吸衰竭。5例非风湿性疾病患者CD4细胞明显下降,HIV阳性,疑似为成人获得性免疫缺陷综合症(AIDS)。4例经纤支镜下肺泡灌洗,检及卡氏肺孢子菌,1例痰液检出肺孢子菌滋养体而确诊PCP。另外3例符合HIV合并PCP诊断标准。8例患者经SMZ—TMP联合克林霉素治疗14d,6例好转,1例效果欠佳转院,1例死亡。结论临床上不明原因发热、呼吸衰竭,胸部影像学进展迅速,常规抗感染效果差患者,应警惕卡氏肺孢子菌肺炎可能,需注意有无服用免疫抑制剂,注意筛查HIV抗体了解有无细胞免疫缺
3、陷。早期、足量、足疗程治疗有助于改善患者预后。关键词:卡氏肺孢子菌肺炎;AIDS;结缔组织疾病;临床分析中图分类号:R519.8文献标识码:AClinicalanalysisofPneumocystiscariniipneumoniaLINMing,LINSheng,ChenYu—sheng,LIHong-ru(DepartmentofRespiratoryMedicine,FujianProvincialMedicineClinicalCollege,FujianMedicineUniversity。Fuzhou350001。Chin
4、a)ABSTRACT:Clinicaldataandtherapeuticsin8casesofPneumocystiscariniipneumonia,whichwasmisdiagnosisedasbac—terialpneumoniafromMay2010toApril2011inFujianProvincialHospital,werereviewedinordertOexploretheclinicallea·turesandmethodsofearlydiagnosisofPneumocystiscariniipneumon
5、ia.Inthese8cases,1hadamitralvalvereplacementwithrheumaticheartdisease10yearago,3caseshadautoimmunediseasesandtookimmunosuppressorforalongtime,andothersdidn'thaveunderlyingdiseases.Allthe8casesappearedfeverofunknownorigin,drycough,shortnessofbreathanddifferentdegreeofresp
6、iratoryfailure.Thefivenon—rheumaticdiseasecasesprovedlowerCD4cellpercentageofTymphocyteandpositiveserumanti—Hn7antibody.ThenPneumocystiscariniiwasfoundintwocasesamongthem。onefrombronchoalveo—larlavagefluid(BALF),anotherfromsputum.Other3caseswasdiagnosedaccordingtoclinica
7、ldiagnosiscriterion.Another3non—HIVcaseswerediagnosisbydetectingPneumocystiscariniiinBALFthroughbronchoscopyfor14days.The8caseswerealltreatedbysulfamethoxazoleandtrimethoprim(SMZ-TMP)andclindamycin,then6gotbetter,1wastransferredtothelazaret,and1wasdead.Inconclusion。forth
8、epatientsappearingfeverwithunknownorigin,unintelligiblerespiratoryfailure。rapidlyprogressinginchestimag
此文档下载收益归作者所有