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1、—464—中华消化杂志2004年8月第24卷第8期ChinJDig,August2004,Vol.24,No.8·论著·加贝酯对Oddi括约肌运动的影响吴叔明徐华戈之铮莫剑忠陈胜良杨川华【摘要】目的观察加贝酯对Oddi括约肌运动功能的影响。方法对我院12例行内镜下逆行胰胆管造影(ERCP)患者于内镜下作Oddi括约肌测压术,记录Oddi括约肌的基础压、基础收缩幅度、收缩-1-1频率和运动指数(基础收缩幅度×收缩频率),并在静脉滴注加贝酯1、3mg·kg·h前后,分别重复以上测压过程。以用药前后记录数
2、据作自身对照配对t检验进行统计学处理。结果①静脉滴注加贝酯-1-11、3mg·kg·h不影响Oddi括约肌的基础压(P>0.05)和基础收缩幅度(P>0.05)。②加贝酯能明-1-1显减少Oddi括约肌的收缩频率(P<0.05),但用药剂量1、3mg·kg·h之间差异无显著性(P>0.-1-1-105)。③大剂量加贝酯可明显降低Oddi括约肌运动指数(P<0.01),且3mg·kg·h与1mg·kg·-1-1h剂量间差异也有显著性(P<0.05)。结论加贝酯能减少人Oddi括约肌的收缩频率,3mg·
3、kg·-1h时还能降低运动指数。加贝酯对Oddi括约肌运动的影响可解释加贝酯减少ERCP后胰腺炎的发生。【关键词】加贝酯;Oddi括约肌;压力测定;逆行胰胆管造影EffectsofproteaseinhibitorgabexatemesilateonmotilityofhumanOddi’ssphincterWUShu2ming,XUHua,GEZhi2zheng,etal.DepartmentofGastroenterology,RenjiHospital,ShanghaiSecondMedica
4、lUniversity,Shanghai200001,China【Abstract】ObjectiveToinvestigateeffectsofgabexatemesilateonthemotilityofhumanOddi’ssphincterbyendoscopicmanometry.MethodsTwelvecasesofendoscopicretrogradecholangiopan2-1-1cretography(ERCP)wereinvestigated.Beforeandafteri
5、nfusionofgabexatemesilate1and3mg·kg·h,endoscopicmanometryofOddi’ssphincterwasperformed.Theparametersofbasalpressure,amplitude,fre2quencyofphasiccontractionandmotilityindex(amplitudeperfrequency)weremeasured.Paireddataob2-1-1tainedwasstatisticallyanalyz
6、ed.Results①Gabexatemesilate1and3mg·kg·hneitheraffectedthebasalpressure(P>0.05)northeamplitudeofphasiccontraction(P>0.05).②Gabexatemesilatesignifi2cantlyreducedthefrequencyofcontraction(P<0.05),butnostatisticdifferenceinfrequencyofcontractionwasobserved
7、indifferentdosagegroups(P>0.05).③Highdosegabexatemesilatecouldmarkedlyreducethemotilityindex(P<0.01),therewassignificantdifferencebetweeninfusionofgabexatemesilate1and-1-13mg·kg·h(P<0.05).ConclusionsGabexatemesilatecouldreducethefrequencyofphasiccontra
8、c2-1-1tioninhumanOddisphincter,infusionofgabexatemesilate3mg·kg·hdecreasedmotilityindexaswell.Theresultsuggeststhatgabexatemesilatemaypossiblypreventpost2ERCPpancreatitisduetoitsinhibitingef2fectonmotilityofOddisphincter.【Keywords】Gabex
