银杏叶提取物对慢性阻塞性肺疾病急性加重期患者血管内皮功能的影响

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1、·医院药学·银杏叶提取物对慢性阻塞性肺疾病急性加重期患者血管内皮功能的影响楼黎明，林咸明，董浙清，丁学军，胡丹丹(浙江中医药大学附属第三医院，杭州310005)摘要：目的探讨银杏叶提取物对慢性阻塞性肺疾病急性加重期(AECOPD)患者血管内皮功能的影响。方法将60例AECOPD患者随机分为常规治疗组(CT组)，银杏叶组(GBLE组)，每组30例；并选择同期30例健康体检者作为对照组。两组常规治疗相同，GBLE组每日加用舒血宁注射液20mL静脉滴注，连用2周。酶联免疫吸附法检测血清一氧化氮(NO)、血栓调节

2、蛋白(TM)和血管假血友病因子(vWF)。结果两个治疗组治疗前NO，TM显著低于对照组(P<0.01)，vWF显著高于对照组(P<0.01)。治疗后，两组NO，TM水平较治疗前显著升高(P<0.01)，而GBLE组升高更为显著，与CT组比较有统计学差异(P<0.01)；两组vWF水平较治疗前显著下降(P<0.01)，GBLE组下降较CT组更为显著(P<0.01)。结论银杏叶提取物有显著改善AECOPD患者血管内皮细胞功能的作用，可预防血栓性疾病。关键词：银杏叶提取物；慢性阻塞性肺疾病；急性加重期；内皮细胞

3、中图分类号：R285.6文献标志码：A文章编号：1007-7693(2011)06-0567-03EffectofGinkgoBilobaLeafExtractonFunctionofVascularEndothelialCellofPatientswithChronicObstructivePulmonaryDiseaseinAcuteExacerbationStageLOULiming,LINXianming,DONGZheqing,DINGXuejun,HUDandan(TheThirdAffili

4、atedHospitalofZhejiangTraditionalChineseMedicalUniversity,Hangzhou310005,China)ABSTRACT：OBJECTIVEToinvestigatetheinfluenceofGinkgobilobaleafextract(GBLE)onthefunctionofvascularendothelialcellofpatientswithchronicobstructivepulmonarydiseaseinacuteexacerbat

5、ionstage(AECOPD).METHODSSixtypatientswithAECOPDwererandomlydividedintotwogroups:conventionaltreatment(CT)groupandGBLEtreatment(GBLE)group,eachgroupconsistedof30cases,and30healthyadultsservedascontrolgroup.AllAECOPDpatientsweregivenconventionaltreatment,wh

6、ileforthepatientsinGBLEgroup,20mLGBLEweregiventhroughintravenousdripeverydayinadditionfor2weeks.Thelevelsoftheserumnitricoxide(NO),thrombomodulin(TM)andvonWillebrandfactor(vWF)inthebloodsamplesweredeterminedwithenzymelinkedimmunosorbentassay(ELISA).RESULT

7、SThelevelofNOandTMweredecreasedsignificantlyinAECOPDpatientscomparedwithcontrolgroupbeforetreatment(P<0.01).AndthelevelofvWFwaselevatedsignificantlyinAECOPDpatientscomparedwithcontrolgroupbeforetreatment(P<0.01).Afterintervention,thelevelofNOandTMinbothtr

8、eatmentgroupsweresignificantlyelevated(P<0.01),andtheelevationinGBLEgroupwasmoreprominentthanCTgroup(P<0.01).ThelevelofvWFinbothtreatmentgroupswassignificantlydecreased(P<0.01),andthedecreaseinGBLEgroupwasmorepromin