小剂量肝素联合维生素K_1佐治婴幼儿重症支气管肺炎疗效观察

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1、68JBengbuMedCol,lJanuary2008,Vo.l33,No.1[文章编号]1000-2200(2008)01-0068-03#临床医学#小剂量肝素联合维生素K1佐治婴幼儿重症支气管肺炎疗效观察122223邸春阳,郭益新,徐玉新,季松茂,瞿丽平,聂青松[摘要]目的:观察小剂量肝素联合维生素K1佐治婴幼儿重症支气管肺炎疗效及副反应。方法:将42例重症支气管肺炎婴幼儿随机分为治疗组和对照组。除常规治疗方法外,治疗组每次用肝素0.3~0.5mg/kg,维生素K1每次0.3~0.5mg/kg,均每日2次,连用3天后改用每天1次

2、,再用2天后停用,观察两组临床疗效及副反应。结果:治疗组和对照组总有效率分别为95.0%和86.4%,治疗组优于对照组(P<0.05),且治疗组未发现明显副反应。结论:小剂量肝素联合维生素K1佐治婴幼儿重症支气管肺炎临床效果好,副反应少,可以推广应用。[关键词]支气管肺炎;肝素;维生素K1;婴幼儿[中国图书资料分类法分类号]R563.12;R973.2[文献标识码]ATreatmentofseriousbronchopneumoniaininfantswiththeaidoflowdoseofheparinandvitaminK112

3、2223DIChun-yang,GUOY-ixin,XUYu-xin,JISong-mao,QUL-iping,NIEQing-song(1.DepartmentofPediatrics,YangzhouHongquanHospital,JiangduJiangsu225200;2.DepartmentofPediatrics,3.DepartmentofClinicalLaboratories,YangzhouFourthPeople.sHospital,YangzhouJiangsu225000,China)[Abstract]O

4、bjective:TostudytheclinicaleffectsandsideeffectsoflowdoseofheparinandVitaminK1interventiononseriousbronchopneumoniaininfants.Methods:Forty-twoinfantswererandomlydividedintotherapeuticgroupandcontrolgroup.Inadditiontotheroutinetherapy,thetheraneutycgroupwasadministeredhe

5、parin0.3-0.5mg/kg,vitaminK10.3-0.5mg/kgtwiceadayforthreedays,thenonceadayfortwodays;thecontrolgroupreceivedonlytheroutinetherapy.Thecurativeeffectsandsidereactionswereobserved.Results:Thetotaleffectiveratesoftheraneutycgroupandcontrolgroupwere95.0%and86.4%,respectively.

6、Thetheraneutycgroupwasobviouslysuperiortothecontrolgroup(P<0.05),andnoobvioussidereactionswereobserved.Conclusions:TreatmentofseriousbronchopneumoniaininfantswiththeaidoflowdoseofHepairandVitaminK1iseffectiveandpresentslittlesidereaction.Itisworthpopularizing.[Keywords]

7、bronchopneumonia;heparin;vitaminK1;infant肺炎是小儿的常见病,严重威胁我国儿童的健例,男12例,女8例;年龄1个月~3岁。对照组22康,也是婴儿时期主要死亡原因。婴幼儿重症肺炎例,男12例,女10例;年龄1个月~3岁。两组临是儿科常见危重症之一,除呼吸系统病变外,尚有循床均表现为高热、咳嗽、气喘、气急,两肺有细湿罗音环、消化和中枢神经系统的合并症,重症肺炎晚期常及哮鸣音,X线胸片提示支气管肺炎;均合并有心力[1][2]常出现弥散性血管内凝血(DIC)。因此早期用药衰竭或心肌损害,符合文献诊断标准

8、,两组之间改善肺微循环和气道通气功能,对防止重症肺炎的具有可比性。发展及降低病死率有重要作用。本文应用小剂量肝1.2治疗方法两组均采用相同的常规治疗方法,素联合维生素K1佐治婴幼儿重症支气管肺炎20包括抗感染、退热、吸氧