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1、UseR!SeriesEditors:RobertGentlemanKurtHornikGiovanniParmigianiForothertitlespublishedinthisseries,gotohttp://www.springer.com/series/6991AndreaS.FoulkesAppliedStatisticalGeneticswithRForPopulation-basedAssociationStudies123AndreaS.FoulkesUniversityofMassachusettsS
2、choolofPublicHealth&HealthSciences404ArnoldHouse715N.PleasantStreetAmherst,MA01003USAfoulkes@schoolph.umass.eduISBN978-0-387-89553-6e-ISBN978-0-387-89554-3DOI10.1007/978-0-387-89554-3SpringerDordrechtHeidelbergLondonNewYorkLibraryofCongressControlNumber:PCNapplied
3、forcSpringerScience+BusinessMedia,LLC2009Allrightsreserved.Thisworkmaynotbetranslatedorcopiedinwholeorinpartwithoutthewrittenpermissionofthepublisher(SpringerScience+BusinessMedia,LLC,233SpringStreet,NewYork,NY10013,USA),exceptforbriefexcerptsinconnectionwithrevi
4、ewsorscholarlyanalysis.Useinconnectionwithanyformofinformationstorageandretrieval,electronicadaptation,computersoftware,orbysimilarordissimilarmethodologynowknownorhereafterdevelopedisforbidden.Theuseinthispublicationoftradenames,trademarks,servicemarks,andsimilar
5、terms,eveniftheyarenotidentifiedassuch,isnottobetakenasanexpressionofopinionastowhetherornottheyaresubjecttoproprietaryrights.Printedonacid-freepaperSpringerispartofSpringerScience+BusinessMedia(www.springer.com)ToRich,SophieandEllaPrefaceThisbookisintendedtoprovid
6、efundamentalstatisticalconceptsandtoolsrelevanttotheanalysisofgeneticdataarisingfrompopulation-basedassocia-tionstudies.Elementaryknowledgeofstatisticalmethodsatthelevelofa rstcourseinbiostatisticsisassumed.Chapters1{3provideageneraloverviewofthegeneticandepidemio
7、logicalconsiderationsrelevanttothissetting.Topicscoveredinclude:(1)typesofinvestigations,typicaldatacomponentsandfea-turesingeneticassociationstudies,andbasicgeneticvocabulary(Chapter1);(2)epidemiologicalprinciplesrelevanttopopulation-basedstudies,includingconfoun
8、dingande ectmodi cation(Chapter2);(3)elementarystatisticalmethodsforestimatingandtestingassociation(Chapter2);(4)theoverarch-inganalyticalchallengesinhe
