虫媒病毒和其他的动物病毒 - VIRAL ZOONOSES

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1、VIRALZOONOSES1transmissionarthropodvectors(bloodsucking)animalvectorsinhalationinfectedsecretionscontactwithinfectedsecretionsdirectcontactwithinfectedanimalsanimalbites2ARBOVIRUSESRODENTBORNEVIRUSESVECTORUNKNOWN3VIGILANCE45ARBOVIRUSESENCEPHALITISFEBRILEDISEASESHEMOR

2、RHAGICFEVERS6ARBOVIRUSESFAMILYENVELOPEyesyesnoSYMMETRYicosahedralhelicalicosahedralGENOMEssRNA(+ve)ssRNA(-ve)segmenteddsRNA,segmented78ARTHROPODHabitatDiurnalactivityPreferredhostAnnualactivityOverwinteringabilityTransovarialtransmissionVERTEBRATEMigratoryactivityPer

3、sistenceofviremiaClinicalconsequencesReservoir?Deadendhost?9STLOUISENCEPHALITIS10PREVENTIONSURVEILLANCEVECTORCONTROLREPELLENTSCLOTHINGTIMINGOFACTIVITY(ORCANCELLATION)VACCINE11PREVENTIONSURVEILLANCEVECTORCONTROLREPELLENTSCLOTHINGTIMINGOFACTIVITY(ORCANCELLATION)VACCINE

4、12SYLVATIC(JUNGLE)CYCLEarthropodarthropodvertebratemanvertebrate13URBANCYCLEarthropodarthropodmanman14ARBOVIRUSESENCEPHALITISFEBRILEDISEASESHEMORRHAGICFEVERS15ARBOVIRALDISEASEMANYDIFFERENTARBOVIRUSESCAUSEDISEASEOFTENSUB-CLINICALINITIALVIRALREPLICATIONENDOTHELIALCELLS

5、MACROPHAGES/MONOCYTELINEAGEINTERFERON(RNAVIRUSES)VIREMIA16RECOVERYINTERFERONCELL-MEDIATEDIMMUNITYANTIBODYMAYPLAYAROLEDURINGVIREMICPHASE17DIAGNOSISNewYorkerMay200018DIAGNOSISSPECIALIZEDLABS19RESISTANCEIgG20ARBOVIRUSES–ENCEPHALITISDISTRIBUTIONEastUS,CanadaWestUS,Canada

6、,Mexico,BrazilCentralandSAmerica,Texas,FloridaNorthAmericaEastUS,partsEurope,partsAfricaNorthAmericaFAMILYTOGAVIRIDAEEasternequineencephalitisWesternequineencephalitisVenezuelanequineencephalitisFLAVIVIRIDAEStLouisencephalitisWestNilevirusencephalitisBUNYAVIRIDAECali

7、forniaserogroup(LaCrosseetc)21ARBOVIRUSENCEPHALITISSPORADICLOW%INFECTIONS->CLINICALCASESNOTALLCASES->MAJORDISEASECASEFATALITYRATIO(CFR)LOWPROBABLYUNDERDIAGNOSED22EASTERNEQUINEENCEPALITISReservoir:birdsVector:mosquitoSentinelshorse,quail,turkeyChildrenathigherriskCFR~

8、35%~5cases/yearav.CDCtogavirus23WESTERNEQUINEENCEPALITISReservoir:birdsVector:mosquitoSentinelshorse,quail,turkeyChildrenathigherri