Materials for fibrous proteins and connective tissue：纤维蛋白和结缔组织的材料

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1、Chapter8FibrousproteinsMajorfibrousproteinofepithelialtissuesisakeratinMajorfibrousproteinsofconnectivetissueare:CollagenElastinDr.StephenC.Hardies7-3735437Dhardies@uthscsa.eduThefundamentalbuildingblockofakeratinfiberisacoiledcoildimerofatypeIandtype

2、IIkeratinpolypeptide.A.coiledcoilB.C.heptadrepeat:hxxhxxx,where"h"meanshydrophobicand"x"meansanyresidue.a-helixa-helicalcoiledcoildomaina-KeratinWhere:Majorproteinofhair,skin,nails,someoralmucosa;smallamountsinallepithelialcells.Cellularlocation:Intra

3、cellular;notfoundinconnectivetissuesStructure:fibrousbundleofcoil-coileda-helixes.Crosslinks:disulfidebondsMultigenefamily:familymembersdifferby:tissuestructureHardSoftamt.CysMoreLessamt.CrosslinksMoreLessFunction:Provideinsolublestructuralproteinforb

4、odysurfacesTrueorFalse?http://biochem.uthscsa.edu/hardies-bin/survey.pla)Proteinsarelinearchainsofaminoacidswithpolarity.PolaritymeansthatthereisdirectionalitycausedbyadjacentaminoacidsbeingjoinedfromCOOHgrouptoNH2group.Oneendofapolypeptidewillbeterme

5、dtheN-terminusandtheothertheC-terminus.Disulfidebondsarecrosslinksbetweensulfuratomsofeithercysteineresiduesormethionineresidues.c)Analphahelixcanaccommidateanysequenceofaminoacids.CollagenWhere:30%oftotalprotein.Majorproteinofconnectivetissues:bones,

6、tendons,ligaments,basementmembranes,dentin,cementum,(notenamel).Cellularlocation:extracellularmatrix.Structure:triplehelix(tropocollagen).Subsequenttosecretion,tropocollagenisassembledandcrosslinkedtomakeinsolublecollagenfibers.Function:Providestensil

7、estrengthtosoftconnectivetissues.Tissuesthatmustbeelasticbutexhibittensilestrength(e.g.ligaments)haveamixtureofcollagenandelastin.Collagenfibersinbonereinforceagainstfracture.TrueorFalse?http://biochem.uthscsa.edu/hardies-bin/survey.pla)Inwovenbone,co

8、llagenfibersarelaiddowninadisorganizedarray,whereasinlamellarbonetheyarelaiddowninamoreorganizedparallelfashion.b)Wovenboneisstrongerthanlamellarbone.c)Laminarboneismadebyremodelingwovenbone.Featuresofcollagenprimarystructure-Gly-Pro-Met-Gly