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1、best@buchiwww.buchi.comInformationBulletinNumber57/2010LactoseDryPowderInhalationLaboratoryScaleSprayDryingofLactose:AReviewenLaboratoryScaleSprayDryingofLactose:AReviewAuthor:Dr.CordinArpagaus,Dr.Ninabest@buchi57/2010enSchafrothandMarcoMeuriIntroductionSpraydryingisacommonlyprac
2、ticedmethodtoprepareinhalablepowders.ThisstudyreviewsrecentlypublishedscientificworkinthefieldoflactosespraydryingforinhalableapplicationsusingBÜCHIlaboratoryscalespraydryers.ThegenerationsoftheMiniSprayDryer;B-190,B-191andB-290modelsandthenewNanoSprayDryerB-90areillustratedinFig
3、ure1.1997-1994MiniSprayDryerB-190Figure2:ProcessdiagramoftheMiniSprayDryerB-190,B-191andB-290modelswithprocessparametersTheadjustablespraydryingprocessfrom90°Cto210°Cdependingontheparameters:application,thefeedratewassetbetween2mL/minto15mL/min,thedryinggas•inletandoutlettemperat
4、ure,flowratewassettypicallyto40m³/h•samplefeedrate,andthespraygaswas300-700L/h.•dryinggasflowrateandMainlyaqueoussolutionswereprepared1994-2003MiniSprayDryerB-191•spraygasflowbydissolvinganactiveingredient(drug,nanoparticles)andexcipient(lactoseInthepresentedresearchstudies(seean
5、dothers)inwateratdifferentsolidTable4),theinletairtemperaturesrangedconcentrations.Insomestudiesethanolwasaddedtothesolutiontoenhanceevaporation[3,5,7,8].Thesamplevolumevariedbetween50and450mL.Theresultantspraydriedpowderwasseparatedbyacycloneandcollectedinavessel.Theexhaustgaswa
6、sextractedfromthecycloneandfiltered.2003-ongoingMiniSprayDryerB-290Incontrast,thenewNanoSprayDryerB-90isbasedonanewspraydryingconcept,asillustratedinFigure3.A2009-ongoingNanoSprayDryerB-90comparisonwiththetraditionalMiniSprayDryerB-290isgiveninTable1.Thedryinggasenterstheapparatu
7、sfrom2009-ongoingMiniSprayDryerB-290thetopwhereitisheatedtothesetinletFigure1:GenerationsofBÜCHIlaboratoryscalespraydryerswiththeMiniSpraytemperature,flowsthenthroughtheDryer;B-190,B-191andB-290modelsandthenewNanoSprayDryerB-90dryingchamber,andexitsthespraydryerNanoSprayDryerB-90
8、MiniSprayDryerB-290best@buchi57/2010enfo
