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1、EuropeanHeartJournal(2004)25,10–16ClinicalresearchAcarbosereducestheriskformyocardialinfarctionintype2diabeticpatients:meta-analysisofsevenlong-termstudiesabbbbM.Hanefeld*,M.Cagatay,T.Petrowitsch,D.Neuser,D.Petzinna,cM.RuppaCentreforClinicalStudies,GWT,
2、TechnicalUniversity,Dresden,GermanybBayerAG,Wuppertal,GermanycformerlyBayerAG,Wuppertal,GermanyReceived12March2003;receivedinrevisedform8July2003;accepted31July2003KEYWORDSAimsToassessiftreatmentwiththe-glucosidaseinhibitoracarbosecanreduceAcarbose;car
3、diovasculareventsintype2diabeticpatients.Cardiovascularevents;MethodsandresultsThismeta-analysisincludedsevenrandomized,double-blind,Meta-analysis;placebo-controlledacarbosestudieswithaminimumtreatmentdurationof52weeks.Myocardialinfarction;Type2diabetic
4、patientsvalidforsafetywererandomizedtoeitheracarbose(n=1248)Riskreduction;orplacebo(n=932).TheprimaryoutcomemeasurewasthetimetodevelopaType2diabetescardiovascularevent.PrimaryanalysiswasconductedusingCoxregressionanalysis.Theeffectofacarboseonmetabolicp
5、arameterswasalsoinvestigated.Acarbosetherapyshowedfavourabletrendstowardsriskreductionforallselectedcardiovas-culareventcategories.Thetreatmentsignificantlyreducedtheriskfor‘myocardialinfarction’(hazardsratio=0.36[95%Cl0.16–0.80],P=0.0120)and‘anycardiov
6、ascularevent’(0.65[95%Cl0.48–0.88],P=0.0061).Glycaemiccontrol,triglyceridelevels,bodyweightandsystolicbloodpressurealsoimprovedsignificantlyduringacarbosetreatment.ConclusionInterventionwithacarbosecanpreventmyocardialinfarctionandcardio-vasculardisease
7、intype2diabeticpatientswhilemostofthemarealreadyonintensiveconcomitantcardiovascularmedication.©2003PublishedbyElsevierLtdonbehalfofTheEuropeanSocietyofCardiology.4IntroductionpatientsaftertheirfirstMIwasalsomarkedlyhigher.TheOASISstudyreportsdiabetesas
8、anindependentriskTheprevalenceofdiabetesisincreasingworldwidetofactorforlong-termmorbidityandmortalityafteran1epidemicproportions.Owingtoitsassociationwithanepisodeofunstablecoronaryarterydisease.5increasedincidenceofandmortality
