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1、p16、bcl-2在子宫内膜良、恶性病变中的表达及其意义作者：木哈拜提?玉苏甫单位：新疆医科大学第二附属医院病理科，基础医学院病理教研室,基础医学院形态中心,新疆乌鲁木齐【摘要】目的：探讨抑癌基因p16和凋亡抑制基因bcl-2在子宫内膜增生过长、子宫内膜癌中的表达及其意义。方法：采用免疫组织化学方法检测并比较66例子宫内膜增生过长、子宫内膜癌组织中p16、bcl-2的表达。结果：从简单型、复杂型、复杂型伴非典型增生过长到子宫内膜癌p16表达率依次下降，分别为78.6％、57.1％、66.6％和40.5％,子宫内膜癌p16阳性表达率明显低于子宫内膜增生过
2、长(P<0.05),子宫内膜癌中不同组织学分型及分级p16阳性表达差异无统计学意义(P>0.05)。bcl-2在子宫内膜癌与复杂型、非典型增生过长中的表达差异无统计学意义(P>0.05)，但简单型增生过长与复杂型、非典型增生过长和子宫内膜癌中的表达差异有统计学意义(P<0.05)。bcl-2表达随着分化程度降低而降低(P<0.05)。结论：p16、bcl-2在子宫内膜癌的发生中起着一定的作用，尤其是bcl-2在复杂型、非典型增生过长中高表达，可作为临床诊断的辅助指标。【关键词】p16bcl-子宫内膜癌免疫组化 Expre
3、ssionofp16,bcl-2inbenignandmalignantendometriallesionanditssignificance Muhabaiti•Yusufu,GUXia,WUXiao-chuan (DepartmentofPathology,SecondAffiliatedHospital,XinjiangMedcialUniversity,Urumqi830000,China) Abstract：Objective：Toinvestigatetheexpressionsofp16andbcl-2inendometr
4、ialhyperplasia,endometrialcarcinomaandtheirclinicalsignificance.Methods：Paraffinembeddedmaterialsin66casesofendometrialhyperplasiaandendometrialcarcinomawerecollectedandimmunohistochemicalstainswereperformedtodetecttheexpressionsofp16andbcl-2.Results：Expressionsofp16graduallydec
5、reasedfromsimple,complex,complexwithatypicalhyperplasiatoendometrialcarcinoma(78.6%,57.1%,66.6%and40.5%respectively),whichhadstatisticalsignificancebetweenhyperplasiagroupsandcarcinoma(P<0.05).Therewasnosignificantdifferencebetweenexpressionofp16andhistologicaltypes,gradesine
6、ndometrialcarcinoma(P>0.05).Expressionofbcl-2wasnosignificantdifferenceinendometrialcarcinomaandcomplex,atypicalhyperplasia.Therewassignificantdifferenceinsimple,complex,atypicalhyperplasiaandendometrialcarcinoma(P<0.05).Expressionofbcl-2wasnosignificantdifferencewithhisto
7、logicaltypes.Thereexistedasignificantdifferencebetweentheexpressionofbcl-2andhistologicalgrades(P<0.05).Conclusions：Expressionofp16,bcl-2mayplayrolesinendometrialcarcinomadevelopment,especially,higherexpressionincomplex,atypicalhyperplasia.Itmaybeatargetfordifferentialdiagnos
8、is. Keywords：p16;bcl-2;endometrialcarcinoma;im
