生物反应器课件 New technologies in cell culture

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1、NewtechnologiesincellcultureContentIntroductionComparisonSensortechnologiesIntroduction-bioreactorsIntroduction-bioreactorsCapableofbeingoperatedasepticallyforanumberofdays,weeksandevenmonthsCapableofgeneratingrepeatableprocessconditionsforanumberofdays,weeksandeve

2、nmonthsAdequateaerationandagitationshouldbeprovidedtomeetthemetabolicrequirementsofthemicro-organismorcellpH,Oxygen,TemperatureandothercontrolshouldbeprovidedSamplingfacilitiesshouldbeprovidedShouldbesuitableforarangeofprocessesShouldbeconstructedtoensuresmoothinte

3、rnalsurfaces(cleanability)µ-FlaskTestTubes,Shakeflasks.Increasedaeration.Reducedevaporativeloss.Solidsupport,Re-useable/Autoclavable.MaybeusedwiththeSensorDishReader®.-Flask’sareShakeFlasks-FlaskConfigurationsFrom100ulto4.0mlSensorDishReader®,SDRSensorDishReader®

4、,SDRNon-invasive,online.pHorDissolvedOxygen.NoCalibrationRequired.6-well24-wellExpandableAdditionalSDR’slinkintotheBasicSet.Upto10SDR’sononeLaptop.Noadditionalsoftwarerequiredforexpansion.SDR’sIntegratewith-Flasksµ-Flask’sIntegratewiththeSensorDishReader®Eliminate

5、Well-plateinconsistency.Reduceandequalizeevaporativelossesacrosswell-plates.ObtainonlinepHordissolvedoxygendataforallwells.DOprofiles(all24foreachwell-plate)Polystyreneu-FlaskSensorFlaskReader®,SFRTheSensorFlaskReader,SFRShaker-mountingblue-toothsensorplatform.Shak

6、eFlaskswithDOandpHsensors.(alsosingleDOorpHifdesired)Multiplevolumes(125/250/500/1000ml).Upto9flasksontheplatformatonetime.MicrobialandMammalianApplicationsMicrobialApplications:MonitorpHandDOlevels.Ensureaerobicgrowth.Followcarbonsourceutilizationandexhaustion.Adj

7、ustorbiterspeedstomaintainDOlevelsforbetterscalability.MammalianApplications:AccuratelymonitorpH/pCO2levels.Adjustbicarbonatelevelsmoreaccurately.MonitorDOlevels,adjustorbiterspeedsforbetterscalability.SoftwareIndividualFlaskCalibrationCompleteHardwareHardwareInclu

8、des:Platform.Batteries.Bluetoothadapter.Software.Clamps.Bluetoothrangeof>15ft.Batterylife>3monthsonasinglecharge.(platformcanoperateonsinglebatte