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1、北京医学2015年第37卷第1期·97··心脑宁胶囊专栏··论著·心脑宁胶囊治疗血管性轻度认知功能障碍的疗效观察郭明冬薛庆辉安玉凤【摘要】目的观察心脑宁胶囊治疗血管性轻度认知障碍(vascularcognitiveimpairmentnodementia,VCIND)的临床疗效。方法选择80例VCIND患者,随机分为治疗组和对照组,每组40例。治疗组给予口服心脑宁胶囊,对照组给予口服尼莫地平片。采用简易智能精神状态检查量表(mini-mentalstateexamination,MMSE)和蒙特
2、利尔认知评估(montrealcognitiveassessment,MoCA)等,观察患者的认知功能变化情况,并观察相关安全性指标。结果治疗组总有效率62.5%,对照组总有效率57.9%,有统计学意义(P<0.05);MMSE评分结果显示,治疗组疗后优于疗前(25.98±0.92vs.24.65±0.80,P<0.01);对照组疗后优于疗前(25.53±1.27vs.24.87±0.91,P<0.01);MoCA评分结果显示,治疗组疗后评分优于疗前(24.93±0.97vs.23.28±0.9
3、6,P<0.01),对照组疗后评分优于疗前(24.53±1.03vs.23.11±0.76,P<0.01);两组治疗后MMSE评分比较,治疗组优于对照组(25.98±0.92vs.25.53±1.27,P<0.05);两组治疗后MoCA评分比较,治疗组与对照组无显著差异(24.93±0.97vs.24.53±1.03,P>0.05)。结论心脑宁胶囊对VCIND患者的认知障碍有较好的改善作用,无明显不良反应。【关键词】血管性轻度认知障碍心脑宁胶囊疗效CurativeeffectofXinnaoni
4、ngcapsule-onthetreatmentofmildvascularcognitiveimpairmentnodementiaGuoMingdong,XueQinghui,AnYufeng.DepartmentofGeriatrics,XiyuanHospital,ChinaAcademyofChineseMedicalSciences,Beijing100091,ChinaCorrespondingauthor:GuoMingdong,Email:drgmd@163.com【Abstr
5、act】ObjectiveToevaluatetheclinicalcurativeeffectofXinnaoningCapsuleonvascularcognitiveimpair-mentnodementia.MethodsInthisstudy,80casesofVCINDweredividedrandomlyintotwogroupsincluding40casesinthetrialgroupand40casesinthecontrolgroup.Patientsofthetrial
6、groupweregiventheXinnaoningCapsule(3tablets,tid),whilethoseinthecontrolgroupweregivenNimodipineTablets(1tablet,tid).Allpatientsofthetwogroupsweretreatedfor6months.Acomparisonofthetherapeuticeffectwasmadebetweenbothgroupsbeforeandaftertreat-mentbymini
7、-mentalstateexamination(MMSE)andMontrealcognitiveassessmentscale(MoCA).ResultsTherewassignificantdifferencebetweenthetotaleffectofthetwogroups(P<0.05).ThescoresofMMSEwereallimprovedaftertreatmentinthetreatmentgroupandthecontrolgroup(25.98±0.92vs.24.6
8、5±0.80,25.53±1.27vs.24.87±0.91;allP<0.01).ThescoresofMoCAwereallimprovedaftertreatmentinthetreatmentgroupandthecontrolgroup(24.93±0.97vs.23.28±0.96,24.53±1.03vs.23.11±0.76;allP<0.01),too.AndtheimprovementofMMSEinthetreatmentgroupwassuperiortothatinth