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时间:2019-05-22
《基于不同多叶准直器的胸膜间皮瘤容积旋转调强放疗剂量学比较》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、http://www.cjomp.comdoi:10.3969~.issn.1005—202X.2015.05.005—635一基于不同多叶准直器的胸膜间皮瘤容积旋转调强放疗剂量学比较张富利,蒋华勇,许卫东,王雅棣,高军茂,刘清智,路娜,陈点点,姚波,侯俊,陈建平北京军区总医院放疗科,北京100700【摘要】目的:比较基于两种类型多叶准直器(MultileafCollimator,MLC)的胸膜间皮瘤容积旋转调强放疗(VolumetricModulatedArcTherapy,VMAT)计划差异
2、。材料与方法:回顾性选取l0例因各种无法手术的胸膜间皮瘤患者CT图像,分别采用配置常规多叶准直器(StandarMLC,sMLC)和微型多叶准直器(micro.MLC,mMLC)的医科达直线加速器进行VMAT的计划设计。比较两种计划在靶区(PlanningTargetVolume,PTv)适形度(ConformityIndex,CI)、均匀度(HeterogeneityIndex,m)以及危及器官(OrgansAtRisk,OaR)剂量体积参数方面的异同。结果:与基于sMLC的VMAT计划(sM
3、LC.VMAT)相比,基于mMLC的VMAT计划(mMLC.VMAT)实施效率高(平均实施时间:2.57.41.66minvs3.27.41.65min,P<0.05)。此外,mMLC.VMAT计划靶区适形度和均匀度优于sMLC.VMAT(CI:0.75-40.080.71-4-0.12;HI:1.09-LO.021.11.40.03)。就OARs而言,除心脏的D(尸==o.042)以外,其它各个OARs的剂量体积参数差异均无显著性意义(0.05)。结论:与sMLC.VMAT计划相比,mMLC.
4、VMAT计划不仅明显缩短了治疗时间,提高靶区的覆盖度与均匀性,而且显著降低了心脏的平均受照剂量,有助于减小心血管病的发生风险。【关键词l多叶准直器;胸膜间皮瘤;容积旋转调强放疗;放疗剂量【中图分类号】R734.3;R73O.55【文献标识码】A【文章编号】1005.202X(2015)05.0635.04Dosimetriccomparisonofvolumetric-modulatedarctherapywithdifferentmultileafcollimatorsforpleuralme
5、sotheliomaZHANGFu—li,JIANGHua—yong,XUWei—dong,WANGYa—di,GAOJun-mflo,LIUQing—zhi,LUNa,CHENDian—dian,YAOBo,HOUJun,CHENJian-pingDepartmentofRadiationOncology,GeneralHospitalofBeijingMilitaryRegion,Beijing100700,ChinaAbstract:0bjectiveTocomparethediferen
6、cesoftwotypesofmultileafcollimators(MLC)inthevolumetricmodulatedarctherapy(VMAT)planforpleuralmesothelioma.MethodsTheCTimagesoftenpatientswithinoperablepleuralmesotheliomwereretrospectivelyselected.TheElektalinearacceleratorwithStandarMLC(sMLC)andMic
7、ro-MLC(mMLC)wererespectivelyappliedtodesignVMATtreatmentplans.Theconformityindex(CI)andhomogeneousindex(HI)ofplanningtargetvolume(PTV).andthedose-volumeparametersofo~ansatrisk(OaRs)werecomparedbetweentheVlVlATplanwithsMLC(sMLC-VMaT)andVMATplanwithmML
8、C(mMLC—VMAT).ResultsThedeliverytimeofsMLC—VMATandm/VlLC—VIVlATwas3.27min~1.65minand2.57min~1.66min.respectively.ComparedwithsMLC—V/VlAT,m/VlLC-VMATwasmoreeficient,
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