survivalanalysiscox多因素回归分析

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1、SurvivalAnalysis:AnIntroductionJaineBlayneyBioinformatics,CCRCBj.blayney@qub.ac.uk24/09/2012JKB1DEFINITIONOFSURVIVALANALYSISSurvivalanalysisexaminesandmodelsthetimeittakesforeventstooccur.Events?Couldbe:recurrenceofdisease,death,re-offending,returntodruguse...24/09/2012JKB2SURVIVALTOPI

2、CSWhatthisworkshopcovers:•Introductiontotermscommonlyusedinsurvivalanalysis•Examplesofmostpopularanalysistechniques•SuggestedwaystoevaluateandpresentresultsWhatthisworkshopdoesn’tcover:•In-depthmathematicalformulae,bigsums!•Poweranalysisforsurvival•Interactions24/09/2012JKB3BOTHTHEORYA

3、NDPRACTICE...“Hewholovespracticewithouttheoryislikethesailorwhoboardsshipwithoutarudderandcompassandneverknowswherehemaybecast."LeonardodaVinci,1452-151924/09/2012JKB4SURVIVALTOPICSSpecificareascovered:•Overallandrecurrence-freesurvivaldefinitions•Censoring•Calculating/codingrecurrence

4、-free/overallsurvivalfromdata•Kaplan-Meieranalysis•Sub-groupanalysis•CoxProportionalHazards•Puttingitalltogether24/09/2012JKB5SURVIVALANALYSIS-SOFTWARESurvivalanalysissoftwaretools:•GraphPadPrism•SPSS(copy/licensingavailablefromSchool/IT)•R(opensource:http://cran.r-project.org/).Releva

5、ntRpackages:survival,survcomp,HMISC,Design,MASS24/09/2012JKB6OVERALLANDRECURRENCE-FREESURVIVALDEFINITIONSOverallSurvival(OS)Overallsurvivalreferstothetimeapatientsurvivesafteraparticularevent,e.g.dateoffirsttreatmentordateofsurgery.Ifthepatientisstillalive,OSistakenuntilthelastfollow-u

6、ptime.Ifapatienthasdied,theenddateisthedateofdeath.Thisincludesdeathfromanycause.Recurrence-FreeSurvival(RFS)Recurrence-freesurvivalreferstothetimeapatientsurviveswithoutevidenceofthedisease.End-pointswillvaryanddefinitionswilldependoncontext.Oneexample:•ifapatientrecurs,RFSistakenfrom

7、dateofsurgery/firsttreatmenttodateofrecurrence.•ifapatientisnon-recurring/alivetheenddateisthelastfollow-up.•ifapatientdies(non-recurring),thedateofdeathistheenddate.24/09/2012JKB7SURVIVAL/CENSORINGPatientsmayhavecensoredsurvivaltimesifdeathorrecurrencehasnotyetoccurred(orthereisnoev