2,2',4,4'-四溴联苯醚紫外光解及DNA损伤毒性研究

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1、脚Y¨jii●■-帅8M2Ⅲ0洲5Ⅲ8哪5ABSTRACTBrominatedflameretardantsarewidelyusedinplastics，electronics，construction，textilesandothermaterialsandproductsduetotheirgoodflame—retardantproperty．PBDEiscurrentlyoneofthemostpopularflameretardents．Studieshaveshownthat，PBDEsiSharmfulto

2、theecologicalenvironmentandhumanbody,suchastoxiceffectsorpotentialhealthhazardtoanimalliver,thyroid，reproductivityanddevelopment，neurologyandimmunesystemsandSOon．Inrecentyears，PBDEshavebeendetectedinvariousenvironmentalmediaandlivingorganisms，alsoinhumanfatandbrea

3、stmilkfordifferentconcentrationlevels．Sofar,BDE一47(2,2’，4，4’-tetrapolybrominateddiphenylether)iscurrentlythemostwidelydistributed，thehighestconcentrationsofbiologicalsamples，oneofthemosttoxicpolybrominateddiphenylethercongenersinlivingorganismsandhumanbeings，thusp

4、hotochemicalreactionisthemaindegradationpathwayofBDE47intheenvironment．Therefore，itisofgreatsignificancetostudythephotochemicalreactionofBDE47anditsDNAdamagetoxicity．Theworkofthispaperconsistsoftwoparts：ThefirstpartisthephotochemicalreactionstudiesofBDE47．BDE47sam

5、pleispreparedinourlab．，andthephotochemicalreactionsofitwereconductedin4differentsolventsandacetonitrilewithtwokindsofadditives，respectiBDE47infourreactionandphotolyacetonitrile>DMSO>methan01．ThereiSaninversecorrelationbetweenphotolysisrateandsolventpolarity,theles

6、spolarsolventsfavorBDE47photolysisreaction．PhotodegradationrateBDE47decreasedintheacetonitrileaddingCuOandCu20，indicatingthatoxidantandreductantarenegativetotheoccurrencephotolysis．ThephotolysisreactionBDE47ismainlyconsecutivedebrominationreaction，producinganumber

7、lower-brominateddiphenylethers，theabundancephotoproductsinvarioussolventsreflectthesolventeffecttothephotodissociationpathway．ThesecondpartisBDE47’SDNAdamagetoxicitystudies．Inthisstudy,cytotoxicitymicelymphocytesinducedbyBDE47andits’photoproductsistestbysinglecell

8、gelelectrophoresis(cometanalysis)method．Theresultsshowedthat：(DBDE47iscytotoxicityandinducedDNAdamagemicelymphocytes；thecytotoxicityincreasewiththeconce